ArticleFrontiers in cellular and infection microbiology2026
What makes them stick? A genetic analysis of biofilm formation of an infective endocarditis-causing
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: To identify genes required for biofilm development, we performed transposon-directed insertion site sequencing (TraDIS) in combination with a biofilm formation assay on a fibrin matrix under physiologically relevant flow conditions. Mutant libraries were screened for deficiencies in biofilm formation, followed by pathway enrichment and targeted functional assays. Results: Mutants impaired in biofilm formation were enriched for disruptions in carbohydrate metabolism, cell wall biogenesis, and quorum sensing pathways. The Discussion: These findings provide the first genome-wide characterization of biofilm-associated gene networks in
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