ArticleFrontiers in nutrition2026
Comparative assessment of
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
Background: The liver's central role in xenobiotic metabolism renders it highly susceptible to injury from oxidative stress. Therapeutic drug solutions for liver diseases remain limited. Natural medicinal plants present an option; sprouting is an emerging trend to maximize the plants' bioactivity. This study explores, for the first time, a direct comparative assessment of the hepatoprotective effects of Methods: Wistar rats were grouped into (1) negative control and (2) positive control. Rats in groups 3, 4, and 5 were gavaged with 100 mg/kg BW silymarin (drug control), 500 mg/kg BW of Results: A high dose of APAP induced severe hepatotoxicity, evident in elevated serum liver enzymes, dyslipidemia, oxidative stress, and apoptosis. BN seed and BN sprout extracts attenuated hepatotoxicity, although the BN sprout extract demonstrated significantly superior efficacy. It more effectively normalized lipid profiles, rebalanced liver enzymes, particularly ALT and Conclusion: BN sprout extract exhibits significantly stronger hepatoprotective effects than its seed counterpart against APAP-induced acute liver injury. The pathway mechanism is attributed to enhanced antioxidants and anti-apoptotic activities, likely due to the higher concentration and bioavailability of phytochemicals achieved through the sprouting process.
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Registered trials
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