ArticleFrontiers in physiology2026
Bioinspired engineering of
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Introduction: Polygonum multiflorum (PM), a traditional medicinal herb, is renowned for its regenerative effects on hair growth; however, its therapeutic application has been largely confined to crude extracts. Recent advances have highlighted plant-derived nanovesicles (PDNVs) as natural carriers of bioactive molecules. This study aimed to evaluate the hair growth-promoting potential of nanovesicles derived from the roots of Polygonum multiflorum (PM-NVs). Methods: PM-NVs were isolated from fresh PM roots using differential and density gradient ultracentrifugation. Their morphology was confirmed by transmission electron microscopy. Human dermal papilla cells (DPCs) were treated with PM-NVs to assess proliferation using the CCK-8 assay and β-catenin activation via Western blot and quantitative RT-PCR (qRT-PCR). Results: PM-NVs were spherical and efficiently internalized by DPCs. Treatment with PM-NVs significantly increased DPC proliferation in a dose-dependent manner, upregulated β-catenin protein levels, promoted its nuclear translocation, and enhanced the expression of downstream target genes ( Conclusions: PM-NVs derived from Polygonum multiflorum promote dermal papilla cell (DPC) proliferation and activate β-catenin signaling, resulting in enhanced hair shaft elongation ex vivo. These findings suggest that PM-NVs represent a natural, biocompatible nanovesicle-based approach for hair follicle regeneration and hold potential as a therapeutic option for alopecia.
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