Observational studyDepression and anxiety2026
Cognitive Symptoms and Overall Functioning During Major Depressive Episodes: Correlation Analysis of Patients With Unipolar and Bipolar Disorders.
Observational study in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cognitive Symptoms and Overall Functioning During Major Depressive Episodes: Correlation Analysis of Patients With Unipolar and Bipolar Disorders.Depression and anxiety · 2026Observational
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Authors and funding
4 authors.
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Abstract
Aim: This cross-sectional observational study was designed to characterize global functioning in patients with unipolar depression (UD) and bipolar depression (BD), focusing on the relationship between functional impairment and objectively assessed and subjectively perceived cognitive deficits, as well as to potential domain-specific cognitive-functional patterns across diagnostic groups. Methods: Individuals experiencing a major depressive episode (MDE) in the context of major depressive or bipolar disorder were recruited. Global functioning was assessed with the Functional Assessment Short Test (FAST), objective cognition with the Screen for Cognitive Impairment in Psychiatry (SCIP), and subjective cognition with the Perceived Deficits Questionnaire-Depression-5-item (PDQ-D-5). Group differences were analyzed using Results: A total of 102 patients were recruited: 54 with UD, 48 with BD. Clinically relevant functional impairment was observed in 87% of UD patients and 93.7% of BD patients. BD individuals showed greater global functional impairment than UD patients, with higher FAST total scores (44.5 ± 23.1 vs. 33.5 ± 14.6, Conclusion: MDEs in unipolar and bipolar disorders are associated with marked functional impairment. Perceived cognitive difficulties may impact daily functioning more than objectively assessed deficits, highlighting their clinical relevance. The distinct cognitive-functional profiles in UD and BD patients underscore the importance of domain-specific assessments to guide interventions targeting both symptom remission and functional recovery.
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