ArticleInorganic chemistry frontiers2026
Cytotoxicity and immunogenic cell death studies of water-soluble tetrahedral Ga(iii) or Fe(iii) coordination cages containing a Au(i) anticancer drug as guest.
Article in Inorganic chemistry frontiers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Water-soluble tetrahedral coordination cages of Ga(iii) (1) or Fe(iii) (2) were studied as carriers for FIN and FIN-ester as gold drugs (FIN = triethylphosphine Au(i) complex of 4-mercaptobenzoate or ethyl ester) in solution and in cell culture. Au(i) complexes remained encapsulated inside 1 or 2 at neutral pH even in the presence of serum proteins but were released at mildly acidic pH values (<6.5). The cytotoxicity response of 1 or 2 containing encapsulated FIN was assessed in two different cancer cell lines (human clear cell renal cell carcinoma ccRCC Caki-1 and murine colon carcinoma CT26) as well as normal cells (human fetal lung fibroblasts IMR-90) over a pH range of 7.5-6.2 and compared to the cages alone or gold drug alone. Free gold(i) complexes were the most highly cytotoxic but showed little selectivity for cancer cells compared to normal cells. FIN encapsulated in either Ga(iii) or Fe(iii) cages displayed a more selective cytotoxic response in cancer cell lines compared to normal cells. At mildly acidic pH, Fe-FIN (2a) gave IC
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