ArticleFrontiers in medicine2026
Clinical characteristics and risk factors for severe community-acquired pneumonia in hospitalized children with human metapneumovirus infection in Shanghai: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Development and Validation of a Nomogram for Predicting Severe Respiratory Illness in Children with Isolated Human Metapneumovirus Infection.Children (Basel, Switzerland) · 2026Article
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6 authors.
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Abstract
Background: HMPV is a leading cause of pediatric lower respiratory tract infections, second only to respiratory syncytial virus in causing severe pneumonia in children. Its clinical presentation closely mimics other common respiratory viruses, making diagnosis challenging. This study aimed to characterize the clinical profile and identify independent risk factors for severe community-acquired pneumonia (CAP) in hospitalized children with human metapneumovirus (HMPV) infection. Methods: We conducted a retrospective cohort study of 878 children hospitalized with HMPV-positive CAP at Shanghai Children's Hospital from 2021 to 2024. Patients were classified into mild ( Results: The severe group comprised 28.0% of the cohort. Key clinical manifestations included fever (98.0%), cough (97.6%), wheezing (56.5%), and pulmonary crackles (84.6%). Compared to the mild group, the severe group had significantly higher rates of premature birth, wheezing, elevated inflammatory markers (NLR > 1, PCT > 1 ng/mL, CRP ≥ 50 mg/L), and co-infection with Conclusion: Approximately 28% of hospitalized children with HMPV-positive CAP progress to severe disease. Premature birth, wheezing, elevated inflammatory markers, and co-infection with MP are independent risk factors, which can facilitate early risk stratification and targeted clinical management.
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