ArticleFrontiers in medicine2026
A multicenter retrospective study: risk factors and nomogram construction for pathological escalation of gastric low-grade intraepithelial neoplasia.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Low-grade intraepithelial neoplasia (LGIN) is recognized as a precancerous lesion of gastric carcinoma. However, discrepancies have been observed between initial biopsy findings and post-Endoscopic Submucosal Dissection (ESD) histopathological results. This study aims to develop and clinically validate a multifactorial nomogram for predicting the risk of pathological upgrading in gastric LGIN. Methods: We retrospectively analyzed clinical data from patients who underwent gastric ESD at three hospitals from June 2018 to July 2024. Sixty-eight patients from Zhejiang Provincial Hospital of Chinese Medicine and fifteen patients from Zhejiang Provincial People's Hospital constituted the training cohort; sixty-eight patients from Shaoxing People's Hospital formed the validation cohort. We performed detailed comparisons of 13 baseline patient characteristics and conducted logistic regression analyses. Subsequently, a nomogram was developed and evaluated. Results: The pathological upgrade rate was 54.1%. Independent risk factors included male sex, mixed IIc lesion morphology, clear demarcation lines, lesion size ≥ 15 mm, and Helicobacter pylori antibody positivity. The area under the receiver operating characteristic curve (AUC) of the training cohort was 0.891, with a sensitivity of 0.882 and specificity of 0.592, indicating strong discriminative ability. The calibration curve closely aligned with the diagonal, suggesting excellent predictive accuracy. DCA indicated significant clinical benefit. The predictive performance of the constructed nomogram in the validation cohort is moderate, with an AUC of approximately 0.67. Conclusion: This multicenter retrospective study identified several independent risk factors for pathological escalation of LGIN to high-grade intraepithelial neoplasia (HGIN) or gastric cancer, including mixed lesion morphology, clear demarcation lines, and lesion size ≥ 15 mm. Further prospective studies are warranted to validate the nomogram's performance across diverse clinical settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.