Multimodal management of late-stage Bockenheimer disease complicated by severe anemia and coagulopathy: a case report.

Zilu Wang, Mingzhe Wen, Qianyun Han, Deming Wang, Lixin Su, Xindong Fan

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Zilu WangDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Mingzhe WenDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Qianyun HanDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Deming WangDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Lixin SuDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Xindong FanDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Funding

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6 · The paper itself

Abstract

Background: Bockenheimer disease is a rare subtype of venous malformations that involves all tissue planes of an upper extremity. This condition progresses throughout life and may cause pain, swelling, hematologic complications, and loss of function. Management for Bockenheimer disease remains challenging. Case presentation: This study presents a case of a 14-year-old girl with late-stage Bockenheimer disease complicated by severe anemia and coagulation disorder. The patient underwent anticoagulation therapy initially, followed by sclerotherapy combined with local suture ligation twice, and received anticoagulants and molecular targeted medication on maintenance post-discharge. Follow-up after 9 months demonstrated a marked improvement in the general condition and significant volume reduction in the affected limb. Laboratory test results revealed recovery of anemia and well-controlled coagulopathy. Complications included contracture in the left elbow. Conclusion: Management for Bockenheimer disease requires multimodal therapy, including sclerotherapy, resection, molecular targeted medication, and anticoagulation throughout the entire process. Prompt intervention at an early stage is crucial to the prognosis. Close attention should be paid to the hematologic profiles, especially during the perioperative period.

Indexed as

anemiaBockenheimer diseasecase reportcoagulopathysclerotherapyvenous malformation

Identifiers

PMID42145732

DOI10.3389/fmed.2026.1791321

PMCPMC13171330

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