ArticleFrontiers in medicine2026
The relationship between corneal biomechanics and endothelial morphology: evidence from a Saudi cohort.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Corneal biomechanics and endothelial morphology are key to ocular stability, but their relationship in healthy adults remains understudied. Methods: In this cross-sectional study, 122 healthy Saudi adults aged 18-40 years were examined using the Ocular Response Analyzer (ORA) to measure corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). Corneal endothelial morphology and central corneal thickness (CCT) were assessed using non-contact specular microscopy, providing endothelial cell density, cell count, hexagonality, and morphometric indices. Measurements were obtained under standardized conditions. Associations between biomechanical, endothelial, and refractive variables were evaluated using ANOVA, Pearson correlation analysis, and multivariate regression models. Results: Males showed slightly lower CH, CRF, and endothelial indices, though differences were not significant. IOPg was significantly higher in hyperopes versus myopes ( Conclusion: Corneal biomechanics in healthy adults are predominantly driven by central corneal thickness, with endothelial morphology exerting a secondary modulatory influence on pressure-related and viscoelastic responses. These findings provide foundational normative data with relevance for refractive surgery, glaucoma assessment, and regional screening practices.
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