Evidence map›Paper›PMID 42145710›Full record

ArticleFrontiers in medicine2026

Outcome of amniotic membrane transplantation in ocular GVHD-related corneal melting: a retrospective case series.

Xin-Yu Zhuang, Yao Xu, Zheng-Tai Sun, Yue Xu, Ying-Jie Chen, Xiao-Wen Tang, Feng Chen, Xiao Ma, Xiao-Jing Shi, Xiao-Feng Zhang

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xin-Yu ZhuangDepartment of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yao XuDepartment of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zheng-Tai SunDepartment of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yue XuDepartment of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ying-Jie ChenDepartment of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiao-Wen TangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Feng ChenNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiao MaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiao-Jing Shi *The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Xiao-Feng Zhang *Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the outcome of single amniotic membrane transplantation (AMT) in the treatment of corneal melting associated with ocular graft-versus-host disease (oGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT), and to explore the correlative risk factors. Methods: A retrospective case series study. Data of 303 patients with oGVHD were reviewed, and cases of corneal melting undergoing AMT were collected. Patients were divided into the single-AMT success group and the single-AMT failure group according to the recurrence of corneal melting within 6 months after receiving the initial AMT. The preoperative ocular assessments (including corneal fluorescence staining, conjunctival congestion, lid margin lesion score, and corneal optical coherence tomography) and characteristics related to HSCT were compared between the two groups. Results: A total of 31 patients were enrolled in this retrospective study, comprising 21 males (67.74%). At 6 months after the initial AMT, 21 cases achieved corneal healing, while corneal melting recurred in 10 cases. There were no differences in the primary disease and donor sources between the single-AMT success group and the failure group. The incidence of lung GVHD in the failure group was higher than that in the success group (OR = 8.021, 95% CI: 1.379 to 64.902, Conclusion: Amniotic membrane transplantation can be used as a treatment for oGVHD-related corneal melting. Lung GVHD may be associated with the failure of single AMT surgery. It is recommended to strengthen postoperative immune regulation and follow-up management.

Indexed as

amniotic membrane transplantation (AMT)corneal meltingdry eyegraft versus-host disease (GVHD)ocular surface

Identifiers

PMID42145710
PMCPMC13171574

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