ArticlemedRxiv : the preprint server for health sciences2026
Ancestry-specific and multi-ancestry genome-wide association studies of restless legs syndrome.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Restless legs syndrome (RLS) is a common neurological disorder that disrupts sleep and quality of life, yet its genetics has been examined almost exclusively in individuals of European ancestry. We performed genome-wide association analyses of RLS in African (2,176 cases; 153,313 controls), Latin American (2,024 cases; 91,902 controls), and European (36,993 cases; 639,182 controls) ancestry groups, followed by a multi-ancestry meta-analysis. We leveraged biobank-based cohorts that established RLS diagnosis using validated clinical criteria, allowing for precise phenotypic characterization. We performed ancestry-specific association studies and post-GWAS approaches to prioritize candidate genes. Our analyses revealed ancestry differences in the genetics of RLS. At the
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