Evidence map›Paper›PMID 42145626›Full record

ArticlemedRxiv : the preprint server for health sciences2026

One-Year Brain Structural Changes Are Associated with Postoperative Delirium and Delayed Resolution of Interleukin-6.

Jinglei Lv, Jennifer Taylor, Samantha Curtis, Kaitlin Kramer, David Kunkel, Shalini Thakur, Veena Nair, Matthew I Banks, Robert A Pearce, Vivek Prabhakaran and 2 more

2 registry-linked trialsAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01980511 completednot on this map

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

TypeobservationalSponsorMcMaster UniversityRan2014 to 2018Enrolled1,116ConditionsCovert Postoperative Stroke
NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinglei LvCentral Clinical School, Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-4906-2646
Jennifer TaylorCentral Clinical School, Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW, Australia.
Samantha CurtisRoyal Prince Alfred Hospital, Camperdown, NSW, Australia.
Kaitlin KramerRoyal Prince Alfred Hospital, Camperdown, NSW, Australia.
David KunkelDepartment of Anaesthesiology, University of Wisconsin, Madison, WI, USA.
Shalini ThakurDepartment of Anaesthesiology, University of Wisconsin, Madison, WI, USA.
Veena NairDepartment of Radiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-5666-3239
Matthew I BanksDepartment of Anaesthesiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-1936-7529
Robert A PearceDepartment of Anaesthesiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-1516-6260
Vivek PrabhakaranDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Richard LennertzDepartment of Anaesthesiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-3273-9056
Robert D SandersCentral Clinical School, Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW, Australia.

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

Background: Postoperative delirium is a common complication in older adults and is associated with neuroinflammation and cognitive decline. Previous studies have shown that the number of surgical procedures is associated with hippocampal volume loss in older adults in a large-scale UK Biobank study. However, it remains unclear whether hippocampal volume loss within one year after surgery is associated with postoperative delirium. Methods: Longitudinal structural MRI data and blood biomarkers were collected before surgery and one year postoperatively from 62 participants (>65 years, 27 females) undergoing major non-intracranial surgery. Hippocampal and other subcortical volumes were quantified using FreeSurfer. Cortical thickness was measured for cortical regions defined by the Desikan-Killiany (DK) atlas. One-year structural changes were examined in relation to peak Delirium Rating Scale (DRS) scores and one-year changes in plasma interleukin (IL)-6 levels. Results: One-year volume loss in the right hippocampus was significantly correlated with postoperative peak DRS scores and the one-year change in IL-6. Additional gray matter reductions were observed in the right putamen and the right superior parietal cortex. Right putamen volume loss was also associated with the one-year change in IL-6, while cortical thinning in the right superior parietal cortex was associated with peak DRS scores. Conclusions: Postoperative delirium is associated with longitudinal gray matter loss following surgery. Delayed resolution of inflammation may also contribute to postoperative brain structural changes. Clinical trial registration: NCT01980511 and NCT03124303.

Indexed as

Hippocampus volume lossiL6 biomarkerNeuroinflammationPostoperative Delirium

Identifiers

PMID42145626
PMCPMC13174729

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.