Evidence map›Paper›PMID 42145604›Full record

ArticlemedRxiv : the preprint server for health sciences2026

NeuroDev: etiology and experience of neurodevelopmental disorders in Kenya and South Africa.

Patricia Kipkemoi, Emily O'Heir, Mutaz Amin, Sarah L Stenton, William Baddoo, Harrison Brand, Zandre Bruwer, Sam Bryant, Eunice Chepkemoi, Björn Christ and 34 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Patricia KipkemoiNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Emily O'HeirThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Mutaz AminThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Sarah L StentonThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
William BaddooThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Harrison BrandCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.
Zandre BruwerDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Sam BryantThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Eunice ChepkemoiNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Björn ChristDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Emma EastmanDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Claire FourieDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Jack M FuCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.
Alice GalvinThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Stacey HallThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Heesu Ally KimThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Fatima KhanDepartment of Neurology, Harvard Medical School, Boston MA, USA.
Collins KipkoechNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Martha KombeNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Rachael MapenziNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Brigitte MellyDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Celia van der MerweThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Beatrice MkubwaNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Serini MurugasenDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Katini MwangashaNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Paul MwangiNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Samuel MwasambuNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Alfred NgomboNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Javan NyaleNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Ikeoluwa Osei-OwusuThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Jessica E RingshawDepartment of Neurology, Harvard Medical School, Boston MA, USA.
Kathryn A RussellThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Kaitlin E SamochaCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.ORCID 0000-0002-1704-3352
Alba Sanchis-JuanCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.
Moriel Singer-BerkThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Grace E VanNoyThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Michal ZieffDepartment of Neurology, Harvard Medical School, Boston MA, USA.
Michael E TalkowskiCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.
Anne O'Donnell-LuriaThe Broad Institute of MIT and Harvard, Cambridge MA, USA.
Christina Austin-TseCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.
Charles R NewtonNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Amina AbubakarNeuroscience Unit, KEMRI-Wellcome Trust, Center for Geographic Medicine Research Coast, Kilifi, Kenya.
Kirsten A DonaldDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.
Elise B RobinsonCenter for Genomic Medicine, Massachusetts General Hospital, Boston MA, USA.

Funding

Joint Center for Mendelian GenomicsUM1HG008900 · NHGRI · BROAD INSTITUTE, INC. · PI O'DONNELL-LURIA, ANNE, REHM, HEIDI L · 2016 to 2020
$16.5M
Rare genetic disorders in NeuroDev: Insight into the genetic and phenotypic heterogeneity of ID, ASD and ADHD in South African PopulationsU01MH119689 · NIMH · BROAD INSTITUTE, INC. · PI DONALD, KIRSTY, O'DONNELL-LURIA, ANNE · 2019 to 2023
$5.2M
A powerful web-based discovery platform for rare disease geneticsR01HG009141 · NHGRI · BROAD INSTITUTE, INC. · PI QUINLAN, AARON R, REHM, HEIDI L · 2017 to 2020
$2.9M
NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan CoastR01HD102975 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI ABUBAKAR, AMINA, NEWTON, CHARLES · 2021 to 2025
$2.6M
Improving Genetic Diagnosis for African Ancestry PopulationsR01HG012781 · NHGRI · BROAD INSTITUTE, INC. · PI Anne O'Donnell-Luria · 2023 to 2026
$1.9M
NHGRI NIH HHS R01 HG009141NHGRI NIH HHS R01 HG012781NHGRI NIH HHS UM1 HG008900NICHD NIH HHS R01 HD102975NIMH NIH HHS U01 MH119689Wellcome Trust
6 · The paper itself

Abstract

The NeuroDev study, conducted in Kenya and South Africa, is a large-scale clinical, genetic, and epidemiologic characterization of neurodevelopmental disorders (NDDs) on the African continent. NeuroDev assessments capture birth, demographic, and developmental history; cognitive and behavioral outcomes; and physical health variables. DNA samples are collected for exome sequencing and clinical genetic analysis. This paper presents novel data from 521 children with NDDs, 739 of those children's parents, and 255 unrelated, typically-developing children. The analyses offer unique genetic and phenotypic characterizations of NDDs in two African countries and underscore the importance of including underrepresented populations in NDD research. Ultimately, 107 children with NDDs from the NeuroDev cohort (22.1%) had likely pathogenic or pathogenic variants in established NDD genes. High rates of genetic diagnosis were associated with high rates of environmental risk factors for NDDs. All data, materials, and measures generated from this study are publicly available through the US National Institute of Mental Health.

Identifiers

PMID42145604
PMCPMC13174726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.