ArticleBJUI compass2026
Perioperative antibiotic prophylaxis, prostate size and transperineal prostate biopsy.
Article in BJUI compass, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Transperineal prostate biopsy (TPPB) is increasingly used for prostate cancer diagnosis due to low postoperative infection rates. However, the necessity of perioperative antibiotics remains debated. Although infectious complications such as urinary tract infections (UTIs) are uncommon, acute urinary retention (AUR) is a recognized complication. This study compared infection rates between patients undergoing TPPB with versus without perioperative antibiotics and evaluated rates of AUR and its association with prostate size. Methods: We conducted a multi-institutional retrospective review of patients who underwent TPPB from 2012 to 2025. Patients were stratified by receipt of perioperative antibiotics (second- or third-generation cephalosporin) versus no antibiotics. Infection was defined as fever ≥38.3°C with or without UTI symptoms or a positive urine culture (>10 Results: A total of 904 patients were included (771 antibiotics and 133 no antibiotics). Eighteen patients (2.0%) developed infection, with no significant difference based on antibiotic usage ( Conclusions: Perioperative antibiotics did not reduce infection rates following TPPB. Larger prostate volume is associated with an increased risk of AUR after TPPB.
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