Effect of serratus anterior plane block versus fentanyl for postoperative pain control and stress response after minimally invasive cardiac surgery: Randomised controlled study.

Saurabh Varshney, Yogesh Narwat, Anand Prasoon

Abstract read

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Saurabh VarshneyDepartment of Anaesthesiology, Graphic Era Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Yogesh NarwatDepartment of Anaesthesiology, Graphic Era Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Anand PrasoonDepartment of Anaesthesiology, Graphic Era Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minimally invasive cardiac surgery (MICS) causes significant intercostal pain managed traditionally with opioids, risking nausea, hypoventilation and delayed recovery. Therefore, it is of interest to compare ultrasound-guided serratus anterior plane block (SAPB, n=60) versus fentanyl-based analgesia (n=60) in 120 adults undergoing right mini-thoracotomy MICS. SAPB significantly reduced 24-hour opioid requirements (12mg [IQR 8-18] versus 22mg [IQR 15-30] morphine equivalents; p<0.001) and lowered pain scores at rest/coughing (6/12h, all p<0.01). SAPB attenuated stress response (6h cortisol 18.4±6.2 versus 24.9±7.1 ug/dL, p<0.001; IL-6 68 versus 102 pg/mL, p=0.002) and reduced postoperative nausea/vomiting (PONV) (18% versus 35%) without block complications. Thus, we show SAPB as an effective opioid-sparing analgesic technique that enhances recovery and comfort in MICS patients.

Indexed as

cardiac fitness surgerycortisoldrug crookfentanylinterleukin-6minimal invasive cardiac surgery (MICS)postoperative painserratus anterior plane block (SAPB)Surgical stress response

Identifiers

PMID42145437

DOI10.6026/973206300221388

PMCPMC13177139

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.