ArticleBioinformation2026
Relationship between periodontitis and oral cancer: A Mendelian randomization study.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Previous observational studies have found a positive association between periodontitis and oral cancer; however, the causal role of periodontitis in oral cancer has not yet been determined. Mendelian randomization (MR) studies are considered superior to traditional observational studies for causal inferences. Therefore, it is of interest to examine the potential causal link between periodontitis and oral cancers using MR analysis. Data were retrieved from the NHGRI-EBI GWAS Catalogue within MR-Base using the "TwoSampleMR" R package. The analysis employed the inverse variance method, with sensitivity analysis using MR-Egger, weighted median and mode approaches. MR analysis showed no association between periodontitis and oral cancer. However, aggressive periodontitis showed significance (p = 0.001), with an odds ratio of 1.39 (95% CI: 1.14-1.69), indicating causality.
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