Immunohistochemical profiling of prognostic biomarkers in oral squamous cell carcinoma.

Amit Wasti, Shweta Chouhan, Vinod Sargaiyan, Rahul Raviraj Shetty, Lovna Titus, Vidhi Singhania, Miral Mehta

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Amit WastiDepartment of Oral Pathology and Microbiology, Government Dental College, Rajbandha Maidan, Raipur, Chhattisgarh, India.

Shweta ChouhanDepartment of Oral Pathology and Microbiology, R.K.D.F. Dental College and Research Centre, Bhopal, Madhya Pradesh, India.

Vinod SargaiyanDepartment of Oral Pathology and Microbiology, Maharana Pratap College of Dentistry & Research Centre, Gwalior, Madhya Pradesh, India.

Rahul Raviraj ShettyDepartment of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be University) Dental College and hospital, Navi Mumbai, India.

Lovna TitusDepartment of Oral and Maxillofacial Surgery, Sri Sankara Dental College, Akathmuri, Thiruvananthapuram, Kerala, India.

Vidhi SinghaniaDepartment of Oral Pathology & Microbiology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.

Miral MehtaDepartment of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) exhibits heterogeneous behavior, limiting the prognostic value of conventional histopathological grading alone. This study assessed Ki-67, p53, EGFR, E-cadherin and cyclin D1 expression in 120 formalin-fixed, paraffin-embedded OSCC specimens. High expression prevailed: Ki-67 (65.8%), mutant p53 (58.3%), EGFR (52.5%), reduced E-cadherin (60.0%), cyclin D1 (54.2%). Significant correlations emerged - Ki-67 with higher grade (p=0.001), nodal metastasis (p=0.008), advanced stage (p=0.012); E-cadherin loss with nodal spread (p=0.002). These markers serve as adjunctive prognostic biomarkers, improving OSCC risk stratification beyond routine histopathology.

Indexed as

cyclin D1E-cadherinepidermal growth factor receptor (EGFR)immunohistochemistryKi-67Oral squamous cell carcinoma (OSCC)p53prognostic markers

Identifiers

PMID42145360

DOI10.6026/973206300221394

PMCPMC13177082

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