Evidence map›Paper›PMID 42145337›Full record

ArticleBioinformation2026

Life - A glimpse into the phenomenon.

Leszek Konieczny, Irena Roterman, Pawel Spolnik

Abstract readEditorial
In one paragraph

Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leszek KoniecznyDepartment of Medical Biochemistry, Jagiellonian University - Medcial College, 31-034 Krakow, Kopernika 7, Poland.
Irena RotermanDepartment of Bioinformatics and Telemedicine, Jagiellonian University - Medical College, 30-688 Kraków, Medyczna 7, Poland.
Pawel SpolnikDepartment of Medical Biochemistry, Jagiellonian University - Medcial College, 31-034 Krakow, Kopernika 7, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancement to knowledge is the possibility to simulate the living system in in silico technique. Therefore, it is of interest to seek an unambiguous interpretation of life as a phenomenon. To overcome the challenges posed by the complexity of biological information, the scope of this study is narrowed down to the cellular level with cells are categorized into two groups: dividing cells - species life, associated with reproduction and non-dividing cells - individual life. This analysis focuses exclusively on individual life, using the erythrocyte as a model for non-dividing cells where the autonomy as a process dedicated to maintaining the stability of the cell's internal environment is treated as the basis. This capacity to sustain internal conditions is recognized as the primary manifestation of life using an automatic response mechanism to environmental changes, governed by negative feedback loops. Furthermore, self-organization, independent recognition of errors and their remediation are identified as key components of autonomous cellular action, the simulation of which is possible using the incorporated simulation tools to model these selected biological processes.

Indexed as

automatismLifeself-sustainingsurviving

Identifiers

PMID42145337
PMCPMC13177138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.