Evidence map›Paper›PMID 42145215›Full record

ReviewJournal of cachexia, sarcopenia and muscle2026

From Pixels to Prediction: Reviewing the Role of Artificial Intelligence in Body Composition Analysis.

Marta Zerunian, Benedetta Masci, Stefano Nardacci, Federico Perconti, Lapo Nardoni, Vincenzo Solimene, Michela Polici, Francesco Pucciarelli, Tiziano Polidori, Domenico De Santis and 2 more

Abstract readReview
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marta ZerunianDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Benedetta MasciDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Stefano NardacciDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Federico PercontiDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Lapo NardoniDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Vincenzo SolimeneDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Michela PoliciDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Francesco PucciarelliDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Tiziano PolidoriDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Domenico De SantisDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Andrea LaghiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Damiano CarusoDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.ORCID 0000-0001-9285-4764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluation of body composition (BC) is a set of biomarkers, including fat, muscle and bone, that allows the quantification of an individual's composition at different levels of complexity (whole body, tissues, macroscopic and microscopic). Recently, BC has gained medical interest due to its impact on health outcomes in both oncologic and non-oncologic conditions. BC parameters are also valuable for opportunistic screening, offering benefits to patients in prevention and health management. Among non-invasive methods to assess BC, cross-sectional imaging, for example, tomography (CT) and magnetic resonance (MR), can provide quantitative data from exams conducted for other reasons that can significantly aid large-scale health prevention. Recent studies highlight BC's potential in personalized medicine, but challenges like lengthy and poorly repeatable manual segmentation and complex analysis have limited its routine clinical use. Artificial intelligence (AI) can address these issues by simplifying and automating the process, from segmentation to prediction (e.g., automatic muscle segmentation for sarcopenia assessment and AI assessment of BC as opportunistic evaluation during CT scan for other clinical reasons). This review aims to summarize recent advancements in BC and AI, showcasing their synergy in enhancing the management of health conditions, from diagnosis to personalized treatments, while discussing current limitations and future challenges.

Indexed as

Artificial IntelligenceBody CompositionHumansMagnetic Resonance ImagingTomography, X-Ray Computedartificial intelligencebody compositionclinical applicationrisk prediction

Identifiers

PMID42145215
PMCPMC13181601

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.