Evidence map›Paper›PMID 42145201›Full record

ArticleGenes, brain, and behavior2026

Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.

Apurva S Chitre, Elaine K Hebda-Bauer, Michael A Emery, Fei Li, Khai-Minh Nguyen, Yizhi Wang, Riyan Cheng, Oksana Polesskaya, Stanley J Watson, Jun Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Elaine K Hebda-BauerMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Michael A EmeryMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Fei LiMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Khai-Minh NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Yizhi WangDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Riyan ChengDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Stanley J WatsonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Jun LiDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Huda AkilMichigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-3634-0747

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI RICHARDS, JERRY B · 2014 to 2023
$27.4M
Investigating the role of Bmp4 in glial subtype specification and temperamentU01DA043098 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUDA AKIL, Jun Li · 2017 to 2026
$6.9M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Abraham A Palmer · 2024 to 2026
$5.6M
Hope for Depression Research FoundationNIDA NIH HHS P30 DA060810NIDA NIH HHS P30DA060810NIDA NIH HHS P50 DA037844NIDA NIH HHS P50DA037844NIDA NIH HHS U01 DA043098NIDA NIH HHS U01DA043098Office of Naval Research 00014-19-1-2149The Pritzker Neuropsychiatric Research Consortium
6 · The paper itself

Abstract

Studies have shown that substance use liability is associated with novelty seeking, anxiety-like behavior, and pain sensitivity. We examined whether common genetic variation in outbred Sprague-Dawley rats explained variation in behavioral measures from three assays with established links to substance use: locomotor response to a novel environment, elevated plus maze, and tail flick. We estimated single-nucleotide polymorphism heritability and performed genome-wide association analyses using permutation-derived significance thresholds (N = 534-654 rats across traits). Heritability estimates ranged from 0.14 to 0.38 across 11 traits. Three independent loci were identified: chromosome 1 for elevated plus maze open-arm behavior (α = 0.05), chromosome 14 for elevated plus maze immobility (α = 0.10), and chromosome 17 for tail flick latency (α = 0.05). Candidate genes included Slc18a2, Gfra1, and Pdzd8 (chromosome 1); Rel and Bcl11a (chromosome 14); and Eci2 and Eci3 (chromosome 17). We compared these loci with our genome-wide association study of a F

Indexed as

AnxietyNociceptionSubstance-Related DisordersAnimalsBehavior, AnimalGenome-Wide Association StudyMalePolymorphism, Single NucleotideRatsRats, Sprague-Dawley

Identifiers

PMID42145201
PMCPMC13181434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.