ArticleCirculation research2026
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Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sorting Out Vasoreactivity in Pulmonary Arterial Hypertension With SNX29.Circulation research · 2026Article
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Authors and funding
35 authors.
Jason H Karnes *Department of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson (J.H.K., E.K., K. Banerjee, J.F., K.L.M.).ORCID 0000-0001-5001-3334
Changlei Bao *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0000-0002-1773-3986
Shuxin Liang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0000-0002-5663-5326
Timothy ThayerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.T., J.D.W., A.R.H., E.B.).
John ZagorskiDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.ORCID 0000-0001-8133-2418
Samisubbu R NaiduDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.ORCID 0000-0001-9411-660X
James D WestDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.T., J.D.W., A.R.H., E.B.).ORCID 0000-0002-6004-0202
Tae-Hwi Schwantes-AnDepartment of Medical and Molecular Genetics (T.-H.S.-A.), Indiana University, Indianapolis.ORCID 0000-0001-6387-0095
Ehsan KhajoueiDepartment of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson (J.H.K., E.K., K. Banerjee, J.F., K.L.M.).ORCID 0000-0003-4565-7770
Kasturi BanerjeeDepartment of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson (J.H.K., E.K., K. Banerjee, J.F., K.L.M.).ORCID 0000-0003-0661-2211
Hemant K TiwariSchool of Public Health, University of Alabama at Birmingham (H.K.T.).
Juvie FarolDepartment of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson (J.H.K., E.K., K. Banerjee, J.F., K.L.M.).ORCID 0000-0002-6146-3100
Kiana L MartinezDepartment of Pharmacy Practice and Science, University of Arizona R. Ken Coit College of Pharmacy, Tucson (J.H.K., E.K., K. Banerjee, J.F., K.L.M.).ORCID 0000-0001-9209-5139
Dingyuan LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).
Yao NingState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0009-0008-5585-5424
Yanan SunState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0009-0001-6245-8784
Yangfan JiaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).
Jian WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0000-0002-1278-256X
Amit AroraDepartment of Epidemiology and Biostatistics, Mel & Enid Zuckerman College of Public Health, University of Arizona (A.A.).ORCID 0009-0001-8841-0316
Ken BataiDepartment of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY (K. Batai).ORCID 0000-0002-0317-1118
Stephen J HallidayDepartment of Medicine, University of Wisconsin-Madison, Madison (S.J.H.).ORCID 0000-0002-4944-3748
Katie LutzDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH (K.L., A.W., W.C.N.).ORCID 0000-0002-9554-7679
Anna WalsworthDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH (K.L., A.W., W.C.N.).ORCID 0000-0001-7638-5507
Andrea L FrumpDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.ORCID 0000-0002-5972-5079
Olga RafikovaDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.
Zhiyu DaiDivision of Pulmonary, Critical Care Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine in Saint Louis, MO (Z.D.).ORCID 0000-0002-2945-7923
Joe G N GarciaUF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter (J.G.N.G.).ORCID 0000-0002-6934-0420
Il-Man KimDepartment of Anatomy, Cell Biology, and Physiology (I.-M.K.), Indiana University, Indianapolis.ORCID 0000-0002-9268-8337
Anna R HemnesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.T., J.D.W., A.R.H., E.B.).ORCID 0000-0002-2755-5845
Evan BrittainDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (T.T., J.D.W., A.R.H., E.B.).ORCID 0000-0001-5843-3392
Raymond L BenzaIchan School of Medicine, NY (R.L.B.).ORCID 0000-0001-9627-6236
William C NicholsDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH (K.L., A.W., W.C.N.).ORCID 0000-0003-1242-9237
Aiai ChuDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.
Haiyang TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China (C.B., S.L., D.L., Y.N., Y.S., Y.J., J.W., H.T.).ORCID 0000-0001-9537-2891
Ankit A DesaiDepartment of Medicine (J.Z., S.R.N., Y.J., A.L.F., O.R., A.C., A.A.D.), Indiana University, Indianapolis.ORCID 0000-0001-6427-616X
Funding
Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI STEVEN M DUDEK · 2016 to 2026
$24.4MSex Hormones in Pulmonary Arterial HypertensionP01HL108800 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWMAN, JOHN HUGHES · 2012 to 2021
$22.0MNational Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1MGenomic and Circulating Predictors of PAH responseR01HL142720 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Anna R Hemnes · 2019 to 2026
$5.0MThe emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertensionR01HL164791 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea Lee Frump · 2022 to 2026
$3.8MClinical and Mechanistic Understanding of Right Ventricular Steatosis in Pulmonary Arterial HypertensionR01HL155278 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain · 2022 to 2026
$3.8MNovel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8MClinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart FailureR01HL146588 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, FREIBERG, MATTHEW S · 2019 to 2022
$3.4MNetwork Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary HypertensionR01HL163960 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain, Anna R Hemnes · 2022 to 2026
$3.4MMitochondrial Dysfunction in Pulmonary HypertensionR01HL160666 · NHLBI · UNIVERSITY OF ARIZONA · PI Olga Rafikova · 2022 to 2026
$3.3MRisk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH BiobankR01HL160941 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI DESAI, ANKIT A, NICHOLS, WILLIAM C · 2022 to 2025
$3.2MPathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4MFDA HHS R01 FD007627NHLBI NIH HHS P01 HL108800NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL142720NHLBI NIH HHS R01 HL146588NHLBI NIH HHS R01 HL155278NHLBI NIH HHS R01 HL156993NHLBI NIH HHS R01 HL158686NHLBI NIH HHS R01 HL160666NHLBI NIH HHS R01 HL160941NHLBI NIH HHS R01 HL163960NHLBI NIH HHS R01 HL164791NHLBI NIH HHS R01 HL180692NHLBI NIH HHS R24 HL105333NHLBI NIH HHS R42 HL145930NHLBI NIH HHS U01 HL125208
Abstract
backgroundAlthough pulmonary arterial hypertension (PAH) is a rare and fatal disease that is well-characterized, vasodilator-responsive PAH accounts for a minority of cases, with little mechanistic knowledge, but with dramatically improved survival.
methodsBy assembling national cohorts, we evaluated genetic influences on acute vasodilator drug response, a key determinant of the presence of vasodilator-responsive PAH. Differences between hemodynamics at rest and after a PAH-specific vasodilator were tested in a genome-wide association study. Validated loci were functionally tested in cell culture and in a hypoxic mouse model of pulmonary hypertension.
resultsRs8057488 in the sorting nexin 29 (
conclusionsThe data cumulatively suggest SNX29 may contribute to vasodilation partly through reduced store-operated calcium entry and endosomal trafficking of store-operated calcium entry proteins, advancing our understanding of vasodilator-responsive PAH.
Indexed as
Hypertension, PulmonarySorting NexinsVasodilationVasodilator AgentsAnimalsCells, CulturedDisease Models, AnimalGenome-Wide Association StudyHumansMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularPulmonary ArteryVasoconstrictionSorting NexinsVasodilator Agentscalciumcell membranehypoxialungvasodilation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.