Small Molecule Inhibition of Mononegavirales RNA Polymerases.

Claire R Cao, Meer Mohammed, Ge Yang, Dong Wang

Abstract readReview

In one paragraph

Review in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claire R CaoSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.

Meer MohammedSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.

Ge YangSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.

Dong WangSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.ORCID https://orcid.org/0009-0007-0760-8165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The order Mononegavirales includes several non-segmented negative-sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA-dependent RNA polymerase (L protein). Recent discoveries in cryo-electron microscopy (cryo-EM) have elucidated the structures of these polymerases and their interactions with small-molecule inhibitors, providing possible insights for antiviral design. This review summarizes current developments and discoveries in small-molecule inhibition of Mononegavirales polymerases, exploring nucleoside/nucleotide inhibitors that target the catalytic site and non-nucleoside inhibitors that engage allosteric pockets within the L protein. By combining biochemical and structural findings, these studies reveal conserved druggable pockets, providing opportunities for the development of broad-spectrum antivirals drugs against Mononegavirales pathogens.

Indexed as

Antiviral AgentsDNA-Directed RNA PolymerasesEnzyme InhibitorsMononegaviralesRNA-Dependent RNA PolymeraseCryoelectron MicroscopyHumansAntiviral AgentsDNA-Directed RNA PolymerasesEnzyme InhibitorsRNA-Dependent RNA Polymerasecryo‐EMmononegaviralesnon‐nucleoside inhibitornucleoside and nucleotide inhibitorRNA polymerase

Identifiers

PMID42145049

DOI10.1002/jmv.70972

PMCPMC13181354

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.