Evidence map›Paper›PMID 42145043›Full record

ArticleStem cells translational medicine2026

A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain.

Pinghui Li, Yaxi Jiang, Xinghua Pan, Xiangqing Zhu, Baoci Shan, Tingting Pan, Shici Yang, Qinghua Li, Ting Li, Jie Li and 4 more

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Article in Stem cells translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pinghui LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Yaxi JiangDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Xinghua PanThe 920th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, the Key Laboratory of Translational Medicine for Cell Therapy Technology, the National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, Kunming, Yunnan Province 650032, China.
Xiangqing ZhuThe 920th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, the Key Laboratory of Translational Medicine for Cell Therapy Technology, the National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, Kunming, Yunnan Province 650032, China.
Baoci ShanCenter for Applied Research in Nuclear Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 1000493, China.ORCID 0000-0002-2911-3653
Tingting PanCenter for Applied Research in Nuclear Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 1000493, China.
Shici YangDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Qinghua LiDepartment of Medical Imaging, The Second People's Hospital of Baoshan City, Baoshan, 678000, China.
Ting LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Jie LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Lilin ChenDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Rui HeDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Fei XieDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
Gaohong ZhuDepartment of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.ORCID 0009-0005-7068-9944

Funding

Professor Zhu Gaohong's "High-level Talents Training Program" of Yunnan Province RLMY20200010Yunnan Province High-level Health Technicians (Leading Talents) L-2017002
6 · The paper itself

Abstract

objectiveAging is a pressing global challenge requiring urgent solutions, and the anti-aging potential of mesenchymal stem cells (MSCs) has drawn global attention. This study treated aged macaques with bone marrow mesenchymal stem cells (BMMSCs) and aimed to establish a non-invasive, reliable, specific, and reproducible imaging method for evaluating BMMSCs' therapeutic effects by combining 18F-FDG PET/CT imaging with texture analysis and Statistical Parametric Mapping 8.0 (SPM8.0).

methodsSixteen healthy female macaques were split into three age groups: juvenile, young, and elderly. Baseline 18F-FDG PET/CT imaging was conducted, and only the elderly group received BMMSC transplantation. Brain PET/CT scans were repeated 3 and 6 months post-treatment. PET data were processed using PET Vcar (for metabolic analysis), LIFEx (for texture feature extraction), and SPM8.0 (for pixel-wise statistical mapping).

resultsThe elderly group had a higher metabolic volume (MTV) than the juvenile group, which declined after BMMSC treatment. However, no significant differences in SUVmax, SUVmean, or TLG were found in the elderly group post-treatment. Texture analysis identified SHAPE_Surface and GLZLM_LZLGE as strong classification markers, with ROC curve AUC values of 0.833 and 0.75, respectively. SPM 8.0 analysis showed BMMSCs improved glucose metabolism in the entorhinal and auditory cortices of aged macaques.

conclusionsBMMSC treatment improved glucose metabolism in specific functional brain regions (auditory processing, motor ability, cognitive memory, vision, taste, and reproductive systems) of aged macaques. 18F-FDG PET/CT plus texture analysis and SPM8.0 is a credible, accurate quantitative methods for assessing BMMSC efficacy.

Indexed as

AgingBone Marrow CellsBrainFluorodeoxyglucose F18Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationPositron Emission Tomography Computed TomographyAnimalsFemaleMacacaFluorodeoxyglucose F18aginganimal modelsbone marrow mesenchymal stem cellsnervous system

Identifiers

PMID42145043
PMCPMC13181180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.