Evidence map›Paper›PMID 42144895›Full record

ArticleChembiochem : a European journal of chemical biology2026

Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments.

Pavel Barahtjan, Juan M Iglesias-Artola, Kristin Böhlig, Annett Lohmann, André Nadler

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments.Chembiochem : a European journal of chemical biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pavel BarahtjanMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Juan M Iglesias-ArtolaMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Kristin BöhligMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Annett LohmannMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
André NadlerMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID https://orcid.org/0000-0001-6329-3910

Funding

Deutsche Forschungsgemeinschaft TRR83H2020 European Research Council GA 758334
6 · The paper itself

Abstract

Recent progress in glycan research has been driven by widespread implementations of metabolic oligosaccharide engineering. Complementing existing approaches, we here introduce bifunctional, UV-crosslinkable, and clickable N-acetylglucosamine and N-acetylgalactosamine analogues, which enable direct visualization of the intracellular probe distribution as well as distinguishing monomeric and macromolecule-bound fractions. Using this feature, we find that monomeric N-acetylmonosaccharides partition into RNA-rich nuclear compartments such as nuclear speckles and nucleoli. This suggests the existence of spatially separated N-acetylmonosaccharide pools within the nucleoplasm. Taken together, bifunctional N-acetylmonosaccharide probes are versatile discovery tools for probing intracellular localization of monosaccharides.

Indexed as

AcetylgalactosamineAcetylglucosamineCell NucleusMonosaccharidesClick ChemistryHumansAcetylgalactosamineAcetylglucosamineMonosaccharidesclick‐chemistrymonosaccharidenuclear compartmentssugar imaging

Identifiers

PMID42144895
PMCPMC13181228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.