ArticleImmunology and cell biology2026
Functional immune profiling reveals CD4
Article in Immunology and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
T cells integrate signals from antigen and costimulatory receptors to calibrate response magnitude and quality, with genetically encoded programs shaping activation thresholds for immune tolerance and feedback regulation. Coeliac disease (CeD) is an autoimmune disorder with well-defined genetic risk and immune dysregulation triggered by dietary gluten. However, how genetic risk translates into cell-intrinsic functional variation, particularly within the naïve T-cell compartment, remains poorly defined. Here, we developed the T cell momentum assay, a quantitative functional profiling platform combining standardized T-cell activation with defined stimulus withdrawal to measure proliferation, survival and activation dynamics over time. Integrated with the Cyton2 mathematical model, this approach infers cellular fate programs from population-level dynamics, enabling high-resolution analysis of intrinsic T-cell behavior. Applying this assay to naïve T cells from individuals with CeD and healthy donors (HDs), we identified disease-associated abnormalities predominantly in CD4
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