Evidence map›Paper›PMID 42144856›Full record

ArticleChembiochem : a European journal of chemical biology2026

Glucose-Modified Viscosity-Responsive Turn-On Fluorescence Molecular Rotors for Wash-Free Live-Cell Imaging.

Takashi Kanamori, Yuki Sadai, Kenji Hida, Takayuki Tsuduki, Chihiro Nogi, Hiroya Asami, Shun-Ichiro Ogura, Hideya Yuasa

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In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takashi KanamoriSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.ORCID https://orcid.org/0000-0002-1782-9283
Yuki SadaiSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.
Kenji HidaSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.
Takayuki TsudukiSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.
Chihiro NogiSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.
Hiroya AsamiDepartment of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan.
Shun-Ichiro OguraSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.
Hideya YuasaSchool of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.

Funding

Japan Society for the Promotion of Science JP16K16640Japan Society for the Promotion of Science JP18K05352Japan Society for the Promotion of Science JP22K05347Japan Society for the Promotion of Science JP25K08821Japan Society for the Promotion of Science JP25K08853Research Foundation for Opto-Science and TechnologyToyota Physical and Chemical Research Institute
6 · The paper itself

Abstract

The overexpression of glucose transporters (GLUTs) in cancer cells represents a promising diagnostic target. While 2-NBDG, a fluorescent glucose analog, enables GLUT-mediated imaging, it suffers from low brightness and requires high concentrations and washing. Herein, we report the development of turn-on fluorescent probes for GLUTs based on the viscosity-sensitive fluorophore in GFP for a wash-free imaging of prostate cancer cell, PC-3. A series of fluorescent molecular rotors (FMRs) were synthesized by modifying the 2-methyl-4-(p-dimethylaminobenzylidene)-5-imidazolinone (DMAB) core. Structural modifications, such as cyclic amine substitution and julolidine incorporation, enhanced fluorescence quantum yields (Φ

Indexed as

Fluorescent DyesGlucoseGlucose Transport Proteins, FacilitativeOptical ImagingFluorescent Chemosensor CompoundsHumansMolecular StructurePC-3 CellsViscosityFluorescent Chemosensor CompoundsFluorescent DyesGlucoseGlucose Transport Proteins, Facilitativefluorescent probeGFP fluorophoreglycoconjugatemolecular rotorturn‐on fluorescence

Identifiers

PMID42144856
PMCPMC13181232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.