Evidence map›Paper›PMID 42144808›Full record

ArticleJournal of surgical oncology2026

Patient Out-of-Pocket Costs and Healthcare Utilization Related to Mastectomy vs Breast Conservation: A Claims-Based Study.

Ellie M Proussaloglou, Yi Ren, Oluwadamilola M Fayanju, Rachel C Blitzblau, Elizabeth R Berger, Monica Valero, E Shelley Hwang, Stephanie B Wheeler, Rachel A Greenup

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ellie M ProussaloglouDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
Yi RenArtera Inc, Los Altos, California, USA.
Oluwadamilola M FayanjuDepartment of Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rachel C BlitzblauDepartment of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
Elizabeth R BergerDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
Monica ValeroDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
E Shelley HwangDuke Cancer Institute, Durham, North Carolina, USA.
Stephanie B WheelerUNC Gillings School of Global Public Health. Lineberger Cancer Center, Chapel Hill, North Carolina, USA.
Rachel A GreenupDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.

Funding

Effectiveness and implementation of a decision support tool to improve surgical decision making in young women with breast cancerR01CA256877 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENUP, RACHEL ADAMS, ROSENBERG, SHOSHANA M · 2022 to 2025
$2.9M
NCI NIH HHS 1R01CA256877-01A1NCI NIH HHS R01 CA256877
6 · The paper itself

Abstract

BACKGROUND AND

objectivesOut-of-pocket (OOP) costs and healthcare utilization remain unknown for women facing breast conservation and mastectomy.

methodsWomen aged 18-64 who underwent upfront breast cancer surgery were identified from the IBM MarketScan Commercial Claims Database (2014-2017). Surgical groups included lumpectomy+radiation; unilateral mastectomy + /-reconstruction, and bilateral mastectomy + /-reconstruction. Cumulative OOP payments were assessed at 12-month intervals over 4 years postoperatively and adjusted to 2017 USD$. Multivariable regression identified factors associated with increased OOP costs.

resultsOverall, 23,159 underwent lumpectomy with radiation (60%), unilateral mastectomy with (15%) and without (6%) reconstruction, and bilateral mastectomy with (17%) and without (2.6%) reconstruction. Women undergoing bilateral mastectomy+reconstruction were younger than other surgical groups (median age 49 vs. 50-55). In the first year after diagnosis, 1.24 million outpatient visits occurred, 27% of enrollees had inpatient admissions, 23% visited an E.R., and median OOP costs were $5669 (range $0 to $132 125). Cumulative costs were significantly higher in women < 45 yo and for those with greater comorbidities. Median OOP costs declined over time (0-12 months: $3661 vs 48 months: $486). OOP costs were 12% higher (8.9%-15.1%) with mastectomy+reconstruction than lumpectomy+radiation ($6529 vs $5333).

conclusionsOut-of-pocket costs and healthcare utilization differ between equally effective surgical treatment options; mastectomy + reconstruction is costlier for patients than breast conservation.

Indexed as

Breast NeoplasmsHealth ExpendituresMastectomyMastectomy, SegmentalPatient Acceptance of Health CareAdolescentAdultFemaleFollow-Up StudiesHumansMammaplastyMiddle AgedPrognosisYoung Adultbreast‐conserving surgerybreast neoplasmshealth care costsinsurancemastectomyout‐of‐pocket expenses

Identifiers

PMID42144808
PMCPMC13427145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.