Evidence map›Paper›PMID 42144795›Full record

ArticlePathology international2026

Incomplete Intestinal Metaplasia in Pyloric Gland Mucosa of Helicobacter pylori-Naïve Stomachs: A Prospective Multicenter Histopathologic Study.

Shinsuke Suemitsu, Kotaro Shibagaki, Asuka Araki, Yoichi Miyaoka, Koichiro Furuta, Tsuyoshi Mishiro, Masahito Aimi, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shinsuke SuemitsuDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Kotaro ShibagakiDepartment of Endoscopy, Shimane University Hospital, Izumo, Japan.ORCID https://orcid.org/0000-0003-3583-2707
Asuka ArakiDepartment of Pathology, Shimane University Hospital, Izumo, Japan.
Yoichi MiyaokaDepartment of Gastroenterology, Shimane Prefectural Central Hospital, Izumo, Japan.
Koichiro FurutaDepartment of Gastroenterology, National Hospital Organization Hamada Medical Center, Hamada, Japan.
Tsuyoshi MishiroDepartment of Gastroenterology, Unnan City Hospital, Unnan, Japan.
Masahito AimiDepartment of Gastroenterology, Tottori Municipal Hospital, Tottori, Japan.
Yusuke TakahashiDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Satoshi KotaniDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Nobuhiko FukubaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Norihisa IshimuraDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.ORCID https://orcid.org/0000-0001-8039-3155
Mamiko NagaseDepartment of Pathology, Shimane University Hospital, Izumo, Japan.
Shigeru KawabataDepartment of Pathology, Shimane University Hospital, Izumo, Japan.
Daisuke NiinoDepartment of Pathology, Shimane University Hospital, Izumo, Japan.
Ryoji KushimaDepartment of Pathology, Shiga University of Medical Science, Otsu, Japan.
Shunji IshiharaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori (Hp)-naïve gastric mucosa has been characterized histologically by the absence of Hp organisms, atrophy, and intestinal metaplasia (IM). We conducted a prospective multicenter study to clarify the prevalence and clinicopathologic features of IM in the Hp-naïve stomach. Hp-naïve individuals with regional gastric mucosal abnormalities detected by endoscopy were enrolled. Biopsies were obtained from target lesions and adjacent mucosa. IM frequency and Updated Sydney System (USS) scores were assessed by glandular background (pyloric vs. fundic) in both target and adjacent samples. Among 52 target and 56 adjacent samples, pyloric and fundic gland mucosa accounted for 28 and 24 target samples and 21 and 35 adjacent samples, respectively. IM was detected exclusively in pyloric gland mucosa of target lesions (46.4% vs. 0%, p < 0.05) and was absent in adjacent mucosa. Atrophy scores were low overall but significantly higher in pyloric than fundic gland mucosa in both target lesions (median [IQR], 1 [1-2] vs. 0 [0-1], p < 0.05) and adjacent mucosa (1 [1-2] vs. 1 [0-1], p < 0.05). All IM lesions were classified as incomplete type, showing predominant small intestinal-type differentiation with residual gastric foveolar markers. Histological evaluation of Hp-naïve gastric mucosa should be region-specific, with attention to glandular architecture.

Indexed as

Gastric MucosaHelicobacter InfectionsAdultAgedAtrophyFemaleHelicobacter pyloriHumansMaleMetaplasiaMiddle AgedProspective StudiesStomachHelicobacter pyloriintestinal metaplasiapyloric gland mucosa

Identifiers

PMID42144795
PMCPMC13181229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.