ArticleKorean circulation journal2026
Association Between Ratio of Cholesterols and Coronary Artery Stenosis According to Low-Density Lipoprotein-Cholesterol Levels and Statin Use.
Article in Korean circulation journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond LDL-C Targets: The Value of Cholesterol Ratios in Unmasking Residual Risk.Korean circulation journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesLow-density lipoprotein cholesterol (LDL-C) remains the principal therapeutic target in preventing atherosclerotic cardiovascular disease. Nevertheless, coronary artery disease (CAD) may develop even in patients whose LDL-C levels are at recommended targets. Using a contemporary Korean multicenter registry, we examined the association between lipid parameters and CAD in patients with suspected angina, considering statin use and LDL-C levels.
methodsWe analyzed data from 2,410 adults with chest pain who underwent coronary angiography at 21 centers in South Korea (2012-2022). CAD was defined as ≥50% stenosis in major coronary arteries. To address multicollinearity among lipid parameters, principal component analysis-derived components were evaluated in multivariable logistic regression, with additional assessment of model discrimination using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).
resultsAmong the study population (60.1% women), 52.0% were on statins, and 36.5% were diagnosed with CAD, which was more frequent in statin users. The proportion of patients with LDL-C within target ranges was similar between statin users and non-users (p=0.695). Total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio, non-HDL-C/HDL-C ratio, and LDL-C/HDL-C ratio showed significant associations with CAD. These associations remained consistent regardless of statin use or LDL-C levels. Total cholesterol/HDL-C and non-HDL-C/HDL-C ratios moderately improved model performance (NRI: 0.413, IDI: 0.024); LDL-C/HDL-C ratio showed mild improvement (NRI: 0.373, IDI: 0.030).
conclusionsIn this large, real-world Korean cohort, cholesterol ratios showed cross-sectional associations with CAD. These associations remained consistent regardless of statin use or LDL-C levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.