Evidence map›Paper›PMID 42144700›Full record

ArticlePest management science2026

Design and synthesis of thiazolyl hydrazide derivatives as potent antifungal agent.

Tianle Wu, Wei Zhang, Quanshui Wang, Renwu Yu, Yi Wang, Jinguang Guo, Longfei Li, Fei Cao, Li Han, Lijuan Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianle WuCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Wei ZhangCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Quanshui WangCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Renwu YuCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Yi WangCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Jinguang GuoCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Longfei LiCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Fei CaoCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Li HanCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Lijuan WangCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Wan LiCollege of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.ORCID https://orcid.org/0000-0003-0472-8501

Funding

Central Guidance for Local Science and Technology Development Fund Projects Guided by the Central Government No.236Z6505GExcellent Youth Research Innovation Team of Hebei UniversityInnovation Team Project of Hebei Universitythe Foundation of President of Hebei University
6 · The paper itself

Abstract

backgroundFungal pathogen causes a persistent threat to global agricultural productivity. Thiazole and hydrazide derivatives exhibit broad-spectrum and potent antifungal activity, demonstrating significant potential as novel antifungal agents.

resultsIn this article, 45 thiazolyl hydrazide derivatives were designed and synthesized as potential succinate dehydrogenase (SDH) inhibitors. These compounds exhibited broad-spectrum antifungal activity against seven pathogens, notably compounds A5 and A33 showed the most significant activity against Pythium aphanidermatum and Sclerotinia sclerotiorum, and compound A37 with cyclopropyl and 3-chloro-2-fluorophenyl substituents showed significant efficacy against Rhizoctonia cerealis (half-maximal effective concentration (EC

conclusionBioactivity screening and antifungal mechanism suggested the potential of thiazolyl hydrazide derivatives as promising, eco-friendly candidates for the development of novel antifungal agents. © 2026 Society of Chemical Industry.

Indexed as

Antifungal AgentsFungicides, IndustrialHydrazinesThiazolesAlternariaAscomycotaDrug DesignMolecular Docking SimulationPythiumRhizoctoniaStructure-Activity RelationshipSuccinate DehydrogenaseAntifungal AgentsFungicides, IndustrialHydrazinesSuccinate DehydrogenaseThiazolesantifungal activityantifungal mechanismdesign and synthesissuccinate dehydrogenase inhibiterthiazolyl hydrazide

Identifiers

PMID42144700
PMCPMC13453195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.