Evidence map›Paper›PMID 42144613›Full record

ArticleJournal of nanobiotechnology2026

Alleviation of diabetic cardiomyopathy via preventing VCAM1-positive cells from senescence by engineered nanovesicles.

Yang Liu, Shuang Liang, Fan Bu, Pengying Wu, Xueying Zhou, Jing Zhao, Mingzhi Shen, Mengying Wei, Guodong Yang, Lijun Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang LiuDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
Shuang LiangDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
Fan BuThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.
Pengying WuDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
Xueying ZhouDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
Jing ZhaoDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, Xi'an, 710032, China.
Mingzhi ShenThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.
Mengying WeiDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, Xi'an, 710032, China. weimengy@fmmu.edu.cn.
Guodong YangDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, Xi'an, 710032, China. yanggd@fmmu.edu.cn.
Lijun YuanDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. yuanlj@fmmu.edu.cn.

Funding

the Hainan Provincial Key Research and Development Program ZDYF2023SHFZ145the National Key Research and Development Program of China 2024YFA1108402the National Natural Science Foundation of China (NSFC) 82202167the National Natural Science Foundation of China (NSFC) 82373171the Partnership Laboratory Program of Air Force Medical University 2024HB010the Shaanxi Natural Science Foundation of China 2023-JC-JQ-60
6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) involves progressive cardiac dysfunction driven by vascular endothelial injury and cellular senescence. However, precisely targeting pre-senescent cells remains a major therapeutic challenge. Herein, through single-cell RNA sequencing of diabetic mouse hearts, we identified VCAM1 -positive (VCAM1

Indexed as

Cellular SenescenceDiabetic CardiomyopathiesNanoparticlesVascular Cell Adhesion Molecule-1AnimalscGAS-STING Signaling PathwayDiabetes Mellitus, ExperimentalEndothelial CellsHEK293 CellsHumansMaleMembrane ProteinsMiceMice, Inbred C57BLSignal TransductionSTING ProteinMembrane ProteinsSTING ProteinVascular Cell Adhesion Molecule-1cGAS-STING pathwayDiabetic cardiomyopathyEndothelial senescenceMembrane lipid engineeringNanovesiclesTargeted drug delivery

Identifiers

PMID42144613
PMCPMC13352781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.