Evidence map›Paper›PMID 42144560›Full record

ArticleThe British journal of nutrition2026

Krill Oil for Pain in Elders: protocol for a pilot, double-blind, randomised controlled trial to evaluate the efficacy of 4 g/d krill oil supplementation for chronic musculoskeletal pain and mobility limitations in older adults.

Javier A Tamargo, Katarina Simic, Samira Capote, Rene Przkora, Kimberly T Sibille, Yenisel Cruz-Almeida, Steve D Anton

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06580912 (Krill Oil for Pain and Physical Function in Older Adults), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06580912 phase2completednot on this map

Krill Oil for Pain and Physical Function in Older Adults

TypeinterventionalSponsorUniversity of FloridaRan2025 to 2025Enrolled40ConditionsChronic Musculoskeletal PainArmsKrill oil, Mixed vegetable oil
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Javier A TamargoPain Research and Intervention Center of Excellence, https://ror.org/02y3ad647University of Florida, USA.ORCID https://orcid.org/0000-0001-9385-9049
Katarina SimicPain Research and Intervention Center of Excellence, https://ror.org/02y3ad647University of Florida, USA.
Samira CapoteDepartment of Community Dentistry and Behavioral Science, https://ror.org/02y3ad647University of Florida, USA.
Rene PrzkoraDepartment of Anesthesiology, University of Florida, USA.
Kimberly T SibillePain Research and Intervention Center of Excellence, https://ror.org/02y3ad647University of Florida, USA.
Yenisel Cruz-AlmeidaPain Research and Intervention Center of Excellence, https://ror.org/02y3ad647University of Florida, USA.
Steve D AntonClaude D. Pepper Older Americans Independence Center, https://ror.org/02y3ad647University of Florida, USA.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Diversity Supplement for Kristina Bell: Biopsychosocial pain predictors of mobility decline in agingR01AG076082 · NIA · UNIVERSITY OF FLORIDA · PI Stephen Coombes, Yenisel Cruz-Almeida · 2022 to 2026
$3.1M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
NIA NIH HHS L32 AG096730NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757NIA NIH HHS R01 AG076082NIA NIH HHS T32 AG049673
6 · The paper itself

Abstract

Mobility limitations due to chronic musculoskeletal pain are a major contributor to disability in older adults, yet current pharmacological treatments often have limited efficacy and increase the risk of polypharmacy. Omega (ω)-3 PUFA, particularly EPA and DHA, have demonstrated anti-inflammatory and analgesic properties, but are under-consumed among older USA adults. Krill oil, a marine-derived source of EPA and DHA with enhanced bioavailability compared with typical fish oils and additional bioactive compounds such as astaxanthin and choline, may offer a promising nutritional intervention. This pilot study will assess the feasibility and acceptability of a 3-month randomised, double-blind, placebo-controlled trial of krill oil supplementation (4 g/d: 1288 mg EPA + DHA, 0·45 mg astaxanthin, 320 mg choline)

Indexed as

AgingChronic painNutritional supplementationOmega-3 fatty acidsPhysical function

Identifiers

PMID42144560
PMCPMC13286246

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.