Evidence map›Paper›PMID 42144510›Full record

ReviewCurrent pain and headache reports2026

Clinical Efficacy and Risks of Clonidine Infusion for Sedation and Analgesia: A Narrative Review.

Josephine M Feeney, Riley K Noble, Trissha Belle Bautista, Mihir Patel, Alaa Abd-Elsayed, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josephine M FeeneySchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Riley K NobleSchool of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Trissha Belle BautistaDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Mihir PatelDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Shahab AhmadzadehDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA. sahar.shekoohi@lsuhs.edu.
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewSince its introduction in 1966, clonidine, an α RECENT

findingsClonidine preparations have been utilized for various purposes in anesthesia over the past few decades. In this regard, infusions can be used perioperatively as a sedative and analgesic, a one-time bolus, or a continuous infusion. Clonidine infusion reduces opioid requirements and can be used to treat both nociceptive and neuropathic pain after surgical procedures. There is a lack of research on isolated efficacy and risk for sedation related to prominent use as adjunctive therapy. Future research is warranted to investigate clonidine unaccompanied to determine performance and potential. Furthermore, there is a gap in our literature between the efficacy, risk, and side effects of continuous clonidine compared to non-continuous clonidine for analgesia. This narrative review aims to highlight the current state of knowledge of clonidine's pharmacology, indications, efficacy, sedative properties, analgesic ability, and side effects.

Indexed as

Adrenergic alpha-2 Receptor AgonistsAnalgesiaClonidineProcedural SedationHumansInfusions, IntravenousAdrenergic alpha-2 Receptor AgonistsClonidineAnalgesicAnesthesiaClonidineOpioid-sparing effectSedation

Identifiers

PMID42144510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.