ArticleIrish journal of medical science2026
The diagnostic value and mechanistic role of miR-20b-5p in premature coronary artery disease.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPremature coronary artery disease (PCAD) is marked by accelerated progression of atherosclerosis, an increased incidence of adverse cardiovascular events, and a less favorable long-term prognosis.
aimsThe diagnostic potential and mechanistic basis of serum miR-20b-5p in PCAD.
methodsSerum levels of miR-20b-5p, sd-LDL indicators (including particle number, concentration, proportion), and LDL particle diameter were measured. Logistic regression identified risk factors for coronary stenosis severity. Spearman analysis assessed the association between miR-20b-5p and Gensini score. ROC curve analysis evaluated clinical diagnostic utility of miR-20b-5p. Cell experiments validated the regulatory interaction between miR-20b-5p and CCL1, and their effects on oxidative stress and inflammation.
resultsThe sd-LDL index and miR-20b-5p levels were significantly altered in patients with PCAD. Furthermore, miR-20b-5p levels and sd-LDL particle count were also associated with the severity of coronary stenosis.Serum levels of miR-20b-5p showed a significant negative correlation with the Gensini score and could serve as a diagnostic biomarker. miR-20b-5p directly targeted and inhibited CCL1, and its overexpression attenuated ox-LDL-induced oxidative stress and inflammatory reactions in HCAECs.
conclusionsmiR-20b-5p and abnormal small dense low-density lipoprotein are risk factors for evaluating the severity of coronary artery stenosis. Moreover, miR-20b-5p may alleviate vascular endothelial oxidative stress and inflammation by targeting CCL1, making it a potential therapeutic target for early intervention.
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