Evidence map›Paper›PMID 42144460›Full record

ArticleNeuroradiology2026

Woven Endobridge device for ruptured vs. unruptured aneurysms: insights from the WorldWideWEB study.

Franja Dugar, Muhammed Amir Essibayi, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Mahmoud Dibas, Yan-Lin Li, Oktay Algin, Sherief Ghozy, Sovann V Lay and 79 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

89 authors.

Franja DugarDepartment of Radiology, Neuroradiology and Nuclear Medicine, Triemli Hospital, Zurich, Switzerland.
Muhammed Amir EssibayiDepartment of Neurosurgery, Montefiore Medical Center, The Bronx, United States.
Hamza Adel SalimDepartment of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, United States.
Basel MusmarDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, United States.
Nimer AdeebDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, United States.
Mahmoud DibasDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, United States.
Yan-Lin LiNuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Oktay AlginMedical Faculty, Department of Radiology, Ankara University, Ankara, Turkey.
Sherief GhozyDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, United States.
Sovann V LayDepartment of Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Adrien GuenegoDepartment of Neuroradiology, Erasmus Hospital, Brussels, Belgium.
Leonardo RenieriDepartment of Neuroradiology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Joseph CarnevaleDepartment of Neurosurgery and Neuroradiology, NewYork-Presbyterian Hospital, New York, United States.
Guillaume SaliouDepartment of Neuroradiology, University Hospital of Lausanne, Lausanne, Switzerland.
Panagiotis MastorakosDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, United States.
Eimad ShotarDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Markus MöhlenbruchDepartment of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.
Michael KralDepartment of Neurosurgery, Christian Doppler Klinik, Salzburg, Austria.
Charlotte ChungDepartments of Radiology & Neurosurgery, New York University Langone Medical Center, New York, United States.
Mohamed M SalemDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, United States.
Ivan LylykDepartment of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina.
Nicole M CancelliereNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, Toronto, Canada.
Jose Danilo Bengzon DiestroNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, Toronto, Canada.
Paul M ForemanDepartment of Neurosurgery, Orlando Health Neuroscience and Rehabilitation Institute, Orlando, United States.
Hamza ShaikhDepartment of Radiology & Neurosurgery, Cooper University Hospital, Camden, United States.
Vedran ŽupančićDepartment of Neuroradiology, Sisters of Charity Hospital, Zagreb, Croatia.
Muhammad U HafeezDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, United States.
Joshua CatapanoDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, United States.
Muhammad WaqasDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, United States.
Giyas AyberkDepartment of Neurosurgery, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Muhammet ArslanRadiology Department, Pamukkale University, Denizli, Turkey.
James D RabinovNeuroendovascular Program, Massachusetts General Hospital, Boston, United States.
Onur ErgunMemorial Hospital, Radiology Department, Üsküdar University, Skutari, Turkey.
Julian MaingardDepartment of Neuroradiology, Austin Health, Melbourne, Australia.
Clemens M SchirmerDepartment of Neurosurgery and Radiology, Geisinger Medical Center, Danville, United States.
Mariangela PianoDepartment of Neuroradiology, Ospedale Niguarda Ca' Granda, Milan, Italy.
Anna L KühnDepartment of Neuroradiology, UMass Memorial Medical Center, Worcester, United States.
Caterina MichelozziDepartment of Neuroradiology, IRCCS Ospedale San Raffaele, Milan, Italy.
Robert M StarkeDepartment of Neurosurgery, University of Miami, Florida, United States.
Ameer HassanDepartment of Neuroradiology, Valley Baptist Medical Center, Harlingen, United States.
Mark OgilvieDepartments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, United States.
Jesse JonesDepartments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, United States.
Waleed BrinjikjiDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, United States.
Fulvio ZaccagnaOxford Centre for Clinical Magnetic Resonance (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
James T GristOxford Centre for Clinical Magnetic Resonance (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Marios PsychogiosDepartment of Neuroradiology, University Hospital of Basel, Basel, Switzerland.
Marie T NawkaDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thi Dan Linh Nguyen-KimDepartment of Radiology, Neuroradiology and Nuclear Medicine, Triemli Hospital, Zurich, Switzerland.
Bryan PukenasDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, United States.
Jan-Karl BurkhardtDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, United States.
Thien HuynhDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, United States.
Juan Carlos Martinez-GutierrezDepartment of Neuroradiology, The University of Texas Health Science Center at Houston, Houston, United States.
Sunil A ShethDepartment of Neuroradiology, The University of Texas Health Science Center at Houston, Houston, United States.
Diana SlawskiDepartment of Radiology, Division of Neuroimaging and Neurointervention, Stanford University, Stanford, United States.
Rabih G TawkDepartments of Radiology and Neurosurgery, Mayo Clinic, Rochester, United States.
Benjamin PulliDepartment of Radiology, Division of Neuroimaging and Neurointervention, Stanford University, Stanford, United States.
Boris LubiczDepartment of Neuroradiology, Erasmus Hospital, Brussels, Belgium.
Pietro PanniDepartment of Neuroradiology, IRCCS Ospedale San Raffaele, Milan, Italy.
Ajit S PuriDepartment of Neuroradiology, UMass Memorial Medical Center, Worcester, United States.
Guglielmo PeroDepartment of Neuroradiology, Ospedale Niguarda Ca' Granda, Milan, Italy.
Eytan RazDepartments of Radiology & Neurosurgery, New York University Langone Medical Center, New York, United States.
Christoph J GriessenauerDepartment of Neurosurgery, Christian Doppler Klinik, Salzburg, Austria.
Hamed AsadiDepartment of Neuroradiology, Austin Health, Melbourne, Australia.
Adnan SiddiquiDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, United States.
Elad I LevyDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, United States.
Neil HaranhalliDepartment of Neurosurgery, Montefiore Medical Center, The Bronx, United States.
David AltschulDepartment of Neurosurgery, Montefiore Medical Center, The Bronx, United States.
Andrew F DucruetDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, United States.
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Boston, United States.
Christopher J StapletonNeuroendovascular Program, Massachusetts General Hospital, Boston, United States.
Peter KanDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, United States.
Vladimir KalousekDepartment of Neuroradiology, Sisters of Charity Hospital, Zagreb, Croatia.
Pedro LylykDepartment of Neuroradiology, Clínica La Sagrada Familia, Buenos Aires, Argentina.
Srikanth BodduDepartment of Neurosurgery and Neuroradiology, NewYork-Presbyterian Hospital, New York, United States.
Jared KnopmanDepartment of Neurosurgery and Neuroradiology, NewYork-Presbyterian Hospital, New York, United States.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, United States.
Hugo H Cuellar-SaenzDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, United States.
Pascal M JabbourDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, United States.
Frédéric ClarençonDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
Nicola LimbucciInterventional Neurovascular Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Tufail PatankarDepartment of Neuroradiology, Barking, Havering And Redbridge University Hospitals NHS Trust, London, United Kingdom.
Vitor Mendes PereiraNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St. Michael's Hospital, Toronto, Canada.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital, Boston, United States.
Mohammad AlmohammadDepartment of Neuroradiology, Universitätsklinikum Gießen und Marburg, Giessen, Germany.
Andre KemmlingDepartment of Neuroradiology, Universitätsklinikum Gießen und Marburg, Giessen, Germany.
Luca ScarciaDepartment of Neuroradiology, Hôpitaux Universitaires Henri-Mondor, Créteil, France.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Boston, United States.
Peter B SpornsDepartment of Radiology, Neuroradiology and Nuclear Medicine, Triemli Hospital, Zurich, Switzerland. peter.sporns@hotmail.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough the Woven EndoBridge (WEB) device is increasingly used for the treatment of wide-neck intracranial aneurysms, including in the acute rupture setting, comparative evidence assessing the impact of rupture status remains limited. This study compared angiographic, safety, and clinical outcomes between ruptured and unruptured intracranial aneurysms treated with WEB.

methodsWe conducted a retrospective analysis of prospectively collected data from the multicenter cohort registry WorldWideWEB, including consecutive adult patients with intracranial aneurysms treated with the WEB. Patients were stratified into groups of ruptured and unruptured aneurysms. Propensity score matching was used to balance baseline characteristics between both groups. Retreatment rate was the primary outcome. Secondary outcomes included mRS, safety events (thromboembolic complications) and angiographic outcomes (periprocedurally and last follow-up).

resultsAmong 1,220 patients, 342 (28.0%) presented with ruptured aneurysms. Propensity-score-matched analyses revealed no significant difference in thromboembolic complications (11.8% vs. 5.9%, p = 0.056), similar periprocedural adequate occlusion (53.3% vs. 53.8%, p > 0.9), and similar retreatment rates (11.8% (95% CI 7.8-17.6%) vs. 7.1% (95% CI 4.1-12.0%), p = 0.14); however, adequate occlusion at follow-up was lower (82.2% vs. 93.3%, p = 0.002) and functional outcomes were worse (mRS ≥ 2 in 34.1% vs. 21.9%, p = 0.012) among patients with ruptured aneurysms.

conclusionRuptured aneurysms demonstrated expected inferior follow-up functional and angiographic outcomes when compared with unruptured aneurysms, but no difference in retreatment rate and procedural safety. These findings support WEB as a safe and effective treatment option for appropriately selected ruptured intracranial aneurysms in routine clinical practice.

Indexed as

Aneurysm, RupturedIntracranial AneurysmAgedCerebral AngiographyFemaleHumansMaleMiddle AgedPropensity ScoreRegistriesRetrospective StudiesTreatment OutcomeEndovascular treatmentIntracranial aneurysmRuptured intracranial aneurysmWoven EndoBridge device

Identifiers

PMID42144460
PMCPMC13653826

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