ArticleScientific reports2026
Photodynamic therapy-induced anticandidal effects via reactive oxygen species generation from bisdemethoxycurcumin and potassium iodide.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Antimicrobial photodynamic therapy (aPDT) is a promising non-pharmacological approach for managing biofilm-associated fungal infections. In this study, we investigated the antifungal efficacy of a double-agent aPDT system combining bisdemethoxycurcumin (BDMC) as a photosensitizer and potassium iodide (KI) as a photodynamic enhancer against Candida albicans biofilms, with particular emphasis on the underlying reactive oxygen species (ROS)-mediated mechanisms. Mature C. albicans biofilms were treated with BDMC alone (20, 40, and 80 µM), KI alone (100 mM), or their combination, followed by dental blue LED irradiation (430 ± 10 nm LED, 200 mW/cm², 0-100 J/cm²). Biofilm viability was assessed, and ROS generation quantified using fluorescence-based assays and electron paramagnetic resonance spectroscopy. The contribution of specific ROS to antifungal activity was evaluated through Spearman correlation analyses. The combined BDMC-KI aPDT system produced significantly greater biofilm inactivation than single-agent treatments. Enhanced antifungal activity was strongly associated with increased singlet oxygen (
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