Evidence map›Paper›PMID 42144271›Full record

ArticleStatistics in medicine2026

Two-Stage Double-Arm Trial Optimal Design of Restricted Mean Survival Time With Sculpted Critical Region.

Jiashan He, Ruitao Lin, Yaxian Chen, K F Lam

Abstract read
In one paragraph

Article in Statistics in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiashan HeDepartment of Statistics, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0009-0007-7345-7705
Ruitao LinDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-2244-131X
Yaxian ChenInnovent Biologics, Suzhou, China.
K F LamSchool of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong, China.

Funding

ong Kong Metropolitan University HE-FRSF/2025/06
6 · The paper itself

Abstract

We propose an optimal phase II design for double-arm two-stage clinical trials using the restricted mean survival time (RMST) to measure the between-arm difference. In the superiority test of the proposed design, the null hypothesis is rejected when the between-arm RMST difference

Indexed as

Clinical Trials, Phase II as TopicResearch DesignComputer SimulationHumansModels, StatisticalSample SizeSurvival Analysisadaptive designnon‐proportional hazardsoptimal designrestricted mean survival timetwo‐stage design

Identifiers

PMID42144271
PMCPMC13180504

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.