Evidence map›Paper›PMID 42144020›Full record

ArticleRenal failure2026

MEF2A nuclear translocation mediated by ROCK phosphorylation promotes EZH2 expression and peritoneal fibrosis.

Dandan Chen, Zhikang Sun, Ying Xu, Qinglian Wang

Abstract read
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dandan ChenDepartment of Nephrology, Xiangya Hospital Central South University, Changsha, Hunan, China.
Zhikang SunShandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China.
Ying XuShandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China.
Qinglian WangShandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged peritoneal dialysis (PD) frequently leads to peritoneal fibrosis (PF). This study aimed to define the role of the Rho-associated coiled-coil containing protein kinase (ROCK) signaling pathway and its downstream effectors, MEF2A and EZH2, in PF.

Indexed as

Enhancer of Zeste Homolog 2 ProteinMEF2 Transcription FactorsPeritoneal DialysisPeritoneal Fibrosisrho-Associated Kinases1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsCells, CulturedDisease Models, AnimalEpithelial-Mesenchymal TransitionGlucoseHumansMalePeritoneumPhosphorylationProtein Kinase Inhibitors1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanEZH2 protein, ratfasudilGlucoseMEF2 Transcription FactorsProtein Kinase Inhibitorsrho-Associated KinasesEZH2fasudilMEF2APeritoneal fibrosis (PF)ROCK

Identifiers

PMID42144020
PMCPMC13182153

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.