Evidence map›Paper›PMID 42143777›Full record

ArticleThe journal of physical chemistry letters2026

Solvent Environment Influences Molecular Conformation and Electron Transport in Peptides.

Rajarshi Samajdar, Hassan Nadeem, Neil Moghe, Diwakar Shukla, Charles M Schroeder

Abstract read
In one paragraph

Article in The journal of physical chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Role of stereochemistry on electron transport in peptides.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rajarshi SamajdarDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.
Hassan NadeemBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0009-0006-8718-8940
Neil MogheDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.
Diwakar ShuklaDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0003-4079-5381
Charles M SchroederDepartment of Chemical and Biological Engineering, Princeton University, 35 Ivy Lane, Princeton, New Jersey 08540, United States.ORCID 0000-0001-6023-2274

Funding

Elucidating sequence, structural and dynamic basis of the functional regulation of membrane proteinsR35GM142745 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SHUKLA, DIWAKAR · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM142745
6 · The paper itself

Abstract

Hierarchical structures play a key role in governing the electronic properties of peptides. Despite recent advances, establishing clear structure-property relationships that connect the solvent environment, molecular conformation, and electron transport at the single-molecule level remains challenging. Here, we use a combination of single-molecule experiments, molecular dynamics (MD) simulations, and machine learning (ML) analysis to understand how electron transport in peptides depends on solvent conditions for several different environments including water, 2,2,2-trifluoroethanol, acetonitrile, and glycerol. Our results reveal two distinct conductance populations for peptides in water or 2,2,2-trifluoroethanol: a high-conductance state associated with defined secondary structures (β turns or 3

Indexed as

PeptidesSolventsAcetonitrilesElectron TransportGlycerolMachine LearningMolecular ConformationMolecular Dynamics SimulationTrifluoroethanolWateracetonitrileAcetonitrilesGlycerolPeptidesSolventsTrifluoroethanolWater

Identifiers

PMID42143777
PMCPMC13250990

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.