ArticleChemistry & biodiversity2026
Six New Dimeric Monoterpenoid Indole Alkaloids With Antiviral Activity From Gelsemium elegans.
Wei Zhang, Miao He, Han Gao, Man-Mei Li, Jiang-Na Li, Chang-Le Hu, Wen-Jing Wang, Ni-Ping Li, Lei Wang, Wen-Cai Ye
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Wei ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-5057-7794 Miao HeState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Han GaoState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Man-Mei LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Jiang-Na LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Chang-Le HuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Wen-Jing WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.
Ni-Ping LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.ORCID https://orcid.org/0009-0003-4708-0634 Lei WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0001-9242-1109 Wen-Cai YeState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-2810-1001 Funding
Guangdong Basic and Applied Basic Research Foundation 2025A1515010925National Natural Science Foundation of China 82204236National Natural Science Foundation of China 82293681(82293680)National Natural Science Foundation of China 82373750National Natural Science Foundation of China 82430108Science and Technology Key Project of Guangdong Province 2024B1515040014Science and Technology Project in Guangzhou 202102070001Science and Technology Project in Guangzhou 2024B03J1286
6 · The paper itselfAbstract
Six new dimeric monoterpenoid indole alkaloids, geleganidines D-I (1-6), together with six known analogues (7-12), were isolated from the roots of Gelsemium elegans. Compounds 1 and 2 represent the first dimeric Gelsemium alkaloids composed of a humantenine-type unit and a gelsedine-type unit, connected through a carbonyl-derived urea bridge. Compounds 3-6 were new dimeric monoterpenoid indole alkaloids featuring distinct dimerization patterns, including a carbonyl-derived urea bridge (3), azo linkages (4 and 5), and a symmetric C-C-linked dimer (6). Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, including NMR, single-crystal X-ray diffraction, and quantum-chemical ECD calculations. Among the isolates, compounds 4, 5, and 8 exhibited significant in vitro anti-herpes simplex virus type 1 (HSV-1) activity, with IC
Indexed as
Antiviral AgentsGelsemiumHerpesvirus 1, HumanSecologanin Tryptamine AlkaloidsAnimalsCrystallography, X-RayDimerizationDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular StructurePlant RootsStructure-Activity RelationshipAntiviral AgentsSecologanin Tryptamine Alkaloidsantiviral activitydimeric alkaloidsGelsemium elegansherpes simplex virus type 1 (HSV‐1)monoterpenoid indole alkaloids
Identifiers
PMID42143741
PMCPMC13381005
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