Evidence map›Paper›PMID 42143353›Full record

ArticleJournal of translational medicine2026

A multi-omics dissection of INHBA

Jie Wang, Qian He, Jingwen Hu, Lianchong Gao, Nengquan Sheng, Siyu Zhou, Jianfeng Gong, Yun Gu, Hongqi Chen, Yi Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie WangDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qian HeDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingwen HuQueen Mary School, Nanchang University, Nanchang, China.
Lianchong GaoKey Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
Nengquan ShengDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Siyu ZhouDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianfeng GongDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yun GuDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hongqi ChenDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi XuDepartment of Oncology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ting YanDepartment of Thyroid, Parathyroid, Breast and Hernia Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. rubyyan529@163.com.
Zhigang WangDepartment of Gastrointestinal Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. wangzhigang72@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe progression of colorectal cancer (CRC) is profoundly influenced by the tumor microenvironment (TME). However, the spatial functional specialization of cancer-associated fibroblasts (CAFs) in driving malignancy and immune evasion remains poorly defined. This study aims to delineate the spatial and functional heterogeneity of specific CAF subpopulations in CRC.

methodsWe performed single-cell RNA sequencing (scRNA-seq) on CRC tissues and integrated public datasets to map the stromal landscape. Key cellular interactions inferred from scRNA-seq were validated using high-resolution Xenium in situ transcriptomics and further corroborated by public spatial transcriptomics (ST) data and immunohistochemistry (IHC).

resultsScRNA-seq identified two distinct, tumor-enriched CAF subpopulations: INHBA

conclusionOur study reveals a spatial division of labor among CAFs in CRC. The conserved expression of INHBA across both pro-tumorigenic lineages positions it as a central stromal regulator and a promising therapeutic target for simultaneously disrupting tumor invasion and immune evasion. These findings highlight the potential of stroma-targeted strategies in advancing CRC treatment.

Indexed as

Cancer-Associated FibroblastsColorectal NeoplasmsEpithelial-Mesenchymal TransitionImmune ToleranceImmunosuppression TherapyMultiomicsGene Expression Regulation, NeoplasticHumansSpatial TranscriptomicsTumor MicroenvironmentCancer-associated fibroblastsColorectal cancerEpithelial-mesenchymal transitionINHBASingle-cell RNA sequencingSpatial transcriptomicsXenium

Identifiers

PMID42143353
PMCPMC13361464

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.