ArticleBMC nephrology2026
Kidney biopsy analysis of 14 cases of renal disease after unrelated cord blood transplantation.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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- Erratum issued
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19 authors.
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Abstract
objectiveTo evaluate kidney biopsy findings to clarify renal disease in patients after hematopoietic stem cell transplantation (HSCT) using unrelated umbilical cord blood transplantation (UCBT).
methodsWe retrospectively examined 14 patients who underwent UCBT at Toranomon Hospital, Tokyo, Japan, from 2015 to 2023 and subsequently developed kidney injury requiring biopsy.
resultsAt biopsy, median urinary protein was 0.57 g/day (IQR, 0.27-1.67), median serum creatinine was 1.97 mg/dL (IQR, 1.81-2.6), and median eGFR was 25.3 mL/min/1.73 m
conclusionThe coexistence of glomerular, vascular, and tubulointerstitial microangiopathic lesions was associated with mild proteinuria and renal dysfunction after UCBT. These findings suggest a chronic endothelial injury process distinct from classical thrombotic microangiopathy.
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