Evidence map›Paper›PMID 42143274›Full record

ArticleBMC psychiatry2026

Extensive frontal cortex abnormalities and cognitive impairment in methamphetamine use disorder: a comprehensive 3T structural MRI analysis.

Yanan Zhou, Winson Fu Zun Yang, Qiuxia Wu, Yuejiao Ma, Honghong Ren, Yuzhu Hao, Manyun Li, Yunfei Wang, Pu Peng, Ning Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanan ZhouDepartment of Psychiatry, The Second People's Hospital of Hunan Province, Hunan Brain Hospital, Changsha, China.
Winson Fu Zun YangDepartment of Psychological Sciences, College of Arts & Sciences, Texas Tech University, Lubbock, TX, USA.
Qiuxia WuDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yuejiao MaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Honghong RenDepartment of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Yuzhu HaoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Manyun LiDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yunfei WangDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Pu PengDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Ning YuanDepartment of Psychiatry, The Second People's Hospital of Hunan Province, Hunan Brain Hospital, Changsha, China.
Yifan XiongDepartment of Psychiatry, The Second People's Hospital of Hunan Province, Hunan Brain Hospital, Changsha, China.
Yizhuo WangDepartment of Psychiatry, The Second People's Hospital of Hunan Province, Hunan Brain Hospital, Changsha, China.
Tieqiao LiuDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. liutieqiao123@csu.edu.cn.
Qianjin WangDepartment of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China. wangqianjin@email.sdfmu.edu.cn.

Funding

the Health and Family Planning Commission of Hunan Province Project B20180484the National Natural Science Foundation of China 82371501the National Natural Science Foundation of China Joint Fund for Regional Innovation and Development Key Support Projects U22A20302the Natural Science Youth Foundation of Shandong Province ZR2023QH565the Science and Technology Bureau, Changsha Project kq2004106
6 · The paper itself

Abstract

backgroundMethamphetamine (MA) is a substance commonly misused globally, with unclear brain imaging mechanisms impacting cognitive functions. This investigation sought to understand the cognitive traits of individuals with methamphetamine use disorders (MUDs) and relate these to structural brain changes, examined from a comprehensive perspective.

methodsThis research encompassed 45 individuals with MUDs (MUD group) and 43 healthy controls (HC group). The MATRICS Consensus Cognitive Battery (MCCB), including 10 subtests covering 7 cognitive domains, was administered to evaluate cognitive abilities in participants, while a 3.0T MRI scanner was employed to gather structural brain data.

resultsCompared to the HC group, the MUD group displayed reduced gray matter volume in the right insula, left middle frontal, left postcentral, and bilateral angular gyrus, while the left precentral, left postcentral, left superior frontal, left parstriangularis, left supramarginal, and left parsopercularis exhibited decreased cortical thickness (P

conclusionMUDs exhibit altered gray matter morphology in several brain regions, where alterations in frontal cortex thickness may underlie the neuroanatomy of cognitive deficits common to MUDs.

Indexed as

Amphetamine-Related DisordersCognitive DysfunctionFrontal LobeMethamphetamineAdultCase-Control StudiesFemaleGray MatterHumansMagnetic Resonance ImagingMaleNeuropsychological TestsYoung AdultMethamphetamineCognitive traitsCortical thicknessFrontal cortexGray matter volumeMethamphetamine

Identifiers

PMID42143274
PMCPMC13352879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.