SynthesisBMC pregnancy and childbirth2026
Natural history and prognostic significance of fetal choroid plexus cysts: a systematic review.
Synthesis in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Missed cases or unreported signals? Genomic newborn screening and the architecture of what counts.European journal of human genetics : EJHG · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFetal choroid plexus cysts (CPCs) are common incidental findings during mid-trimester ultrasound. Although typically benign, their detection often causes parental concern because of potential associations with chromosomal abnormalities, particularly trisomy 18. This systematic review summarizes current evidence on the natural history, associated anomalies, and prognostic implications of CPCs to guide prenatal counseling.
methodsWe systematically searched PubMed, Scopus, Web of Science, Embase, and the Cochrane Library for original studies published between 2010 and 2025. Eligible studies included fetuses with CPCs diagnosed by ultrasound and reported data on anomalies, genetic testing, or pregnancy outcomes. Case reports and reviews were excluded. Two reviewers independently screened and extracted data. Study quality was assessed using the Newcastle-Ottawa Scale and Joanna Briggs Institute checklists. Findings were synthesized qualitatively due to heterogeneity.
resultsTen studies met inclusion criteria, comprising over 10,600 screened fetuses, with several hundred CPC cases. Prevalence ranged from 0.5% to 2.5%, most detected between 16 and 22 weeks. Isolated CPCs, particularly in pregnancies with normal biochemical screening or negative non-invasive prenatal testing (NIPT), were not significantly associated with chromosomal abnormalities. By contrast, CPCs with additional sonographic findings showed a markedly increased risk of trisomy 18 and clinically significant copy number variations. Most isolated CPCs resolved spontaneously and were followed by favorable neonatal outcomes.
conclusionsIsolated CPCs in the context of low-risk screening should be regarded as benign variants with excellent prognosis, and invasive testing is unnecessary. Conversely, CPCs with additional risk factors require further evaluation, including chromosomal microarray, supporting a risk-adapted approach.
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