ArticleCommunications biology2026
Oscillatory network efficiency predicts mood and fatigue during sleep deprivation.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Fluctuations in performance and mood across the day have been traced to circadian and homeostatic modulation of motor and affective systems, although their combined influence on network topology is rarely considered. We applied a data-driven curve-fitting algorithm to capture both circadian and infradian rhythms ( ≥ 24 hours) in frontolimbic and sensorimotor regions using functional magnetic resonance imaging (fMRI) measures of connectivity. Across the course of sleep deprivation, functional network structure was not static but changed in tandem with objective and subjective behavioral measures. Oscillatory patterns in network efficiency suggest that circadian rhythmicity extends to higher-order network topology. Sleep deprivation affects functional networks in a region-specific manner, highlighting local vulnerability. Distinct cortical regions exhibited unique circadian phases of network reorganization, revealing that connectivity rhythms are spatially as well as temporally differentiated across the brain. Time-dependent alterations in connectome topology offer a systems-level framework for understanding how internal timekeeping and sleep pressure modulate non-linear trends in psychomotor vigilance, mood, and fatigue across extended wakefulness.
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