Evidence map›Paper›PMID 42143131›Full record

ArticleNPJ cardiovascular health2026

Marine microplastic concentration and associations with stroke and chronic disease prevalence.

Sai Rahul Ponnana, El-Hussain Shamsa, Zhuo Chen, Tejas Rajagopalan, Tong Zhang, Santosh Sirasapalli, Skanda Moorthy, Jean-Eudes Dazard, Sadeer Al-Kindi, Salil V Deo

Abstract read
In one paragraph

Article in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sai Rahul PonnanaCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
El-Hussain ShamsaDepartment of Medicine, University Hospitals, Cleveland, OH, USA.
Zhuo ChenCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Tejas RajagopalanUniversity Schools, Cleveland, OH, USA.
Tong ZhangCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Santosh SirasapalliCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Skanda MoorthyCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Jean-Eudes DazardCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Sadeer Al-KindiDivision of Cardiology, Houston Methodist Hospital, Houston, OH, USA.
Salil V DeoCase School of Medicine, Case Western Reserve University, Cleveland, OH, USA. svd14@case.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microplastics (MPs), synthetic polymer particles <5 mm, are emerging environmental contaminants with potential cardiometabolic relevance. We conducted a cross-sectional analysis of 709 coastal census tracts ( < 200 meters from shoreline) by linking NOAA marine microplastic measurements with chronic disease prevalence estimates from the CDC PLACES database. A total of 154 demographic, socioeconomic, and environmental variables including age, sex, race, median household income, Social Vulnerability Index, insurance coverage, and PM2.5 were incorporated to adjust for confounding. Adjusted Poisson regression models showed that tracts with the highest microplastic exposure had higher prevalence of stroke (PR = 1.21, 95% CI: 1.13-1.29), diabetes (PR = 1.17, 95% CI: 1.10-1.24), and hypertension (PR = 1.10, 95% CI: 1.06-1.14) compared with low-exposure areas. Among all covariates, XGBoost models with SHAP interpretation identified microplastic concentration as an important environmental predictor of stroke prevalence. These ecological findings suggest microplastics were associated with chronic disease patterns and warrant further investigation.

Identifiers

PMID42143131
PMCPMC13241525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.