Evidence map›Paper›PMID 42143029›Full record

ArticleNPJ Parkinson's disease2026

Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson's disease and multiple system atrophy.

Amber H van der Stam, Nienke M de Vries, Sharon Shmuely, Susanne T de Bot, Jurgen A H R Claassen, Alessandra Fanciulli, Joanna IntHout, Fabian Kerkhof, Ineke A van Rossum, Joost H W Rutten and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05551377 (The Heads-Up Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05551377 naunknown statusnot on this map

The Heads-Up Trial: Sleeping in a Head-Up Tilt Position to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease

TypeinterventionalSponsorRadboud University Medical CenterRan2023 to 2024Enrolled50ConditionsParkinson Disease, ParkinsonismArmsHead-up tilt sleeping
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Towards the Prevention of Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amber H van der StamDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
Nienke M de VriesDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
Sharon ShmuelyDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
Susanne T de BotDepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Jurgen A H R ClaassenDepartment of Geriatric medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Alessandra FanciulliDepartment of Neurology, Dysautonomia Centre, Innsbruck Medical University, Innsbruck, Austria.
Joanna IntHoutIQ Health Science Department, Radboud University Medical Center, Nijmegen, the Netherlands.
Fabian KerkhofDepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Ineke A van RossumDepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Joost H W RuttenDepartment of Internal Medicine, Division of Vascular Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Daan SmeenkDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
Yue WangDepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Bastiaan R BloemDepartment of Neurology, Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
Roland D ThijsDepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands. R.D.Thijs@lumc.nl.

Funding

Michael J. Fox Foundation for Parkinson's Research MJFF-020200
6 · The paper itself

Abstract

Orthostatic hypotension (OH) and the co-existence with supine hypertension (SH) are debilitating consequences of autonomic failure in Parkinson's disease (PD) and multiple system atrophy (MSA). Head-up tilt sleeping (HUTS) has the potential to treat both simultaneously. Within the Heads-Up trial, 20 persons with PD or MSA and both SH and OH were assigned randomly to two HUTS schemes with gradually increasing angles: 1° (placebo), 6° and 12°; or 6°, 12° and 18°. The effect of increasing the head of the bed (per cm) was analyzed with linear mixed models. HUTS did not reduce nocturnal SBP but improved other indicators of blood pressure control, including early morning supine SBP, nocturnal dipping profile, diurnal SBP and SBP fall upon standing, coinciding with improved orthostatic tolerance. Adherence was 100% at 6°, 80% at 12°, and 60% at 18°. Higher angles were more effective, but at the cost of lower tolerability. The trial is registered at ClinicalTrials.gov (NCT05551377, 19-09-2022).

Identifiers

PMID42143029
PMCPMC13438099

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.