Trial reportThe American journal of clinical nutrition2026
Assessing the responsiveness of musculoskeletal tissues to protein supplementation in vivo in older adults: an exploratory randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03037294 (Protein Turnover in the Osteoarthritic Knee; the Impact of Preoperative Protein Intake and Intra-articular Corticosteroid Injections), which is not on this map. Not yet cited in PubMed.
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Protein Turnover in the Osteoarthritic Knee; the Impact of Preoperative Protein Intake and Intra-articular Corticosteroid Injections
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16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough muscle protein turnover rates have been well established, little is known regarding the turnover of other musculoskeletal tissues. Furthermore, their response to protein supplementation has not yet been assessed.
objectivesTo assess skeletal muscle, bone, cartilage, tendon, ligament, meniscus, and periarticular soft tissue protein synthesis rates over a 2-wk period with or without additional protein supplementation in vivo in older adults.
methodsTwenty-four otherwise healthy older adults (12M/12F; age: 68 ± 7 y; body mass index: 29 ± 5 kg/m
resultsDaily fractional protein synthesis rates (FSRs) in muscle, synovium, and Hoffa's fat pad averaged 1.17 ± 0.23, 0.79 ± 0.46, and 0.53 ± 0.29%/d, respectively. Fibrous tissues, including anterior and posterior cruciate ligament, patellar tendon, lateral and medial meniscus, and femoral cartilage FSRs averaged 0.45 ± 0.27, 0.46 ± 0.32, 0.20 ± 0.10, 0.21 ± 0.15, 0.18 ± 0.14, and 0.19 ± 0.11%/d, respectively. Finally, FSRs of bone obtained from the distal femur, notch, trochlea, tibia, and patella were 0.18 ± 0.13, 0.21 ± 0.14, 0.13 ± 0.10, 0.12 ± 0.05, and 0.16 ± 0.10%/d, respectively. FSR differed significantly between tissue groups (P-tissue group < 0.001), with the highest FSR in muscle, followed by periarticular soft tissues, fibrous tissues, and bone (pairwise comparisons, all P < 0.001). Musculoskeletal tissue FSR did not differ between the control and protein supplemented group (P-treatment = 0.27, P-treatment∗tissue type = 0.14).
conclusionsMuscle, bone, cartilage, tendon, ligament, meniscus, and periarticular soft tissue protein synthesis rates range between 0.12 and 1.17% per day in vivo in older adults. Two weeks of protein supplementation does not seem to increase daily musculoskeletal tissue turnover. This trial was registered at www. CLINICALTRIALS: gov as NCT03037294.
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