High proportions of respiratory and non-respiratory modulated pre-Bötzinger complex neurons receive monosynaptic inputs from the pontine respiratory group in rabbit.

Yin Feng, Matthew L Dillard, Jennifer J Callison, Edward J Zuperku, Astrid G Stucke

Abstract read

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Article in Respiratory physiology & neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Yin FengMedical College of Wisconsin, Milwaukee, WI, United States.

Matthew L DillardMedical College of Wisconsin, Milwaukee, WI, United States.

Jennifer J CallisonMedical College of Wisconsin, Milwaukee, WI, United States.

Edward J ZuperkuMedical College of Wisconsin, Milwaukee, WI, United States.

Astrid G StuckeMedical College of Wisconsin, Milwaukee, WI, United States. Electronic address: astucke@mcw.edu.

Funding

Mechanisms of opioid and sedative-induced respiratory depressionR01HL159546 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STUCKE, ASTRID G · 2021 to 2024

$1.9M

NHLBI NIH HHS R01 HL159546

6 · The paper itself

Abstract

Synaptic drive from the pontine respiratory group (PRG) to the pre-Bötzinger complex (pre-BötC) is an accepted feature of network models of respiratory rhythm and pattern generation. Surprisingly, data on functional analysis of the prevalence of monosynaptic connections to neurons in the pre-BötC are limited. In the in vivo decerebrate rabbit preparation (n = 15), we analyzed post-stimulus time-histograms (PSTH) of n = 501 multi-electrode array recorded pre-BötC neurons after electrical stimulation of the PRG. PSTH analysis revealed short latency (<15 ms) peaks or troughs classified as monosynaptic excitatory or inhibitory pontine synaptic inputs. Overall, 79% of all recorded respiratory neurons received synaptic inputs; 42% received purely excitatory input whereas 31% received both excitatory and inhibitory signals and only 6% of the population received solely inhibitory inputs. Variations of PCO

Indexed as

NeuronsPonsRespirationRespiratory CenterSynapsesAction PotentialsAnimalsElectric StimulationFemaleMaleNeural PathwaysRabbitsIn vivo decerebrate rabbit modelPontine respiratory groupPost-stimulus time-histogramPreBötzinger complexRespiratory rhythm generation

Identifiers

PMID42142686

DOI10.1016/j.resp.2026.104591

PMCPMC13222644

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