Evidence map›Paper›PMID 42142586›Full record

ReviewThe Journal of biological chemistry2026

Transport mechanism of the SLC4 proteins-Lessons from recent structural and computational studies.

Hristina R Zhekova, Alexander Pushkin, Weiguang Wang, Liyo Kao, Kirill Tsirulnikov, Rustam Azimov, Natalia Abuladze, Dora Acuna, Z Hong Zhou, D Peter Tieleman and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hristina R ZhekovaCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Canada.
Alexander PushkinDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Weiguang WangDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA; Electron Imaging Center for Nanosystems, California NanoSystems Institute, University of California, Los Angeles, California, USA.
Liyo KaoDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Kirill TsirulnikovDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Rustam AzimovDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Natalia AbuladzeDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Dora AcunaDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA.
Z Hong ZhouElectron Imaging Center for Nanosystems, California NanoSystems Institute, University of California, Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.
D Peter TielemanCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Canada. Electronic address: tieleman@ucalgary.ca.
Ira KurtzDivision of Nephrology, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, California, USA; Brain Research Institute, University of California, Los Angeles, California, USA. Electronic address: ikurtz@mednet.ucla.edu.

Funding

The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
High-Resolution CryoEM Reconstruction of Large ComplexesR01GM071940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, Z HONG · 2006 to 2025
$5.0M
NIDDK NIH HHS R01 DK077162NIGMS NIH HHS R01 GM071940
6 · The paper itself

Abstract

The solute carrier family 4 (SLC4) secondary transporters are found ubiquitously in animal, plant, and fungal tissues, where they transport HCO

Indexed as

SLC4A ProteinsAnimalsBiological TransportHumansModels, MolecularProtein ConformationSLC4A Proteinsbicarbonate transportcryogenic electron microscopylipid–protein interactionmembrane proteinmolecular modelingprotein conformationsecondary transporterSLC4 familystructure-functionX-ray crystallography

Identifiers

PMID42142586
PMCPMC13263692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.